Diagnosis and management of small bowel neuroendocrine tumors: A state-of-the-art.

Autor:	Gonzáles-Yovera JG; Division of Gastroenterology, María Auxiliadora Hospital, Lima 15801, Peru., Roseboom PJ; Division of Emergency Medicine, Regional Academic Hospital of Trujillo, Trujillo 13011, Peru., Concepción-Zavaleta M; Division of Endocrinology, Stella Maris Clinic, Lima 15084, Peru., Gutiérrez-Córdova I; Division of Gastroenterology, Guillermo Almenara Irigoyen National Hospital, Lima 12590, Peru., Plasencia-Dueñas E; Division of Endocrinology, Guillermo Almenara Irigoyen National Hospital, Lima 12590, Peru., Quispe-Flores M; Division of Endocrinology, Guillermo Almenara Irigoyen National Hospital, Lima 12590, Peru., Ramos-Yataco A; Division of Internal Medicine, Ricardo Cruzado Rivarola Hospital, Ica 110301, Peru. aj96@outlook.es., Alcalde-Loyola C; School of Medicine, National University of Trujillo, Trujillo 13007, Peru., Massucco-Revoredo F; Division of Endocrinology, Guillermo Almenara Irigoyen National Hospital, Lima 12590, Peru., Paz-Ibarra J; Department of Medicine, School of Medicine, National University of San Marcos, Lima 15001, Peru., Concepción-Urteaga L; Division of Internal Medicine, School of Medicine, National University of Trujillo, Trujillo 13011, Peru.
Jazyk:	angličtina
Zdroj:	World journal of methodology [World J Methodol] 2022 Sep 20; Vol. 12 (5), pp. 381-391. Date of Electronic Publication: 2022 Sep 20 (Print Publication: 2022).
DOI:	10.5662/wjm.v12.i5.381
Abstrakt:	This review provides an update on the epidemiology, pathophysiology, symptoms, diagnosis and treatment of neuroendocrine neoplasms (NENs) of the small bowel (SB). These NENs are defined as a group of neoplasms deriving from neuroendocrine cells. NENs are currently the most common primary tumors of the SB, mainly involving the ileum, making the SB the most frequently affected part of the gastrointestinal tract. SB NENs by definition are located between the ligament of Treitz and the ileocecal valve. They are characterized by small size and induce an extensive fibrotic reaction in the small intestine including the mesentery, resulting in narrowing or twisting of the intestine. Clinical manifestations of bowel functionality are related to the precise location of the primary tumor. The majority of them are non-functional NENs and generally asymptomatic; in an advanced stage, NENs present symptoms of mass effect by non-specific abdominal pain or carcinoid syndrome which appears in patients with liver metastasis (around 10%). The main manifestations of the carcinoid syndrome are facial flushing (94%), diarrhea (78%), abdominal cramps (50%), heart valve disease (50%), telangiectasia (25%), wheezing (15%) and edema (19%). Diagnosis is made by imaging or biochemical tests, and the order of request will depend on the initial diagnostic hypothesis, while confirmation will always be histological. All patients with a localized SB NEN with or without near metastasis in the mesentery are recommended for curative resection. Locoregional and distant spread may be susceptible to several therapeutic strategies, such as chemotherapy, somatostatin analogs and palliative resection. Competing Interests: Conflict-of-interest statement: All the authors declare no conflict of interest. (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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