In Vivo Longitudinal Monitoring of Cardiac Remodeling in Murine Ischemia Models With Adaptive Bayesian Regularized Cardiac Strain Imaging: Validation Against Histology.
Autor: | Mukaddim RA; Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA. Electronic address: mukaddim@wisc.edu., Weichmann AM; Small Animal Imaging and Radiotherapy Facility, University of Wisconsin-Madison, Madison, Wisconsin, USA., Taylor R; Cardiovascular Physiology Core Facility, University of Wisconsin-Madison, Madison, Wisconsin, USA., Hacker TA; Cardiovascular Physiology Core Facility, University of Wisconsin-Madison, Madison, Wisconsin, USA., Pier T; Experimental Animal Pathology Lab, University of Wisconsin-Madison, Madison, Wisconsin, USA., Hardin J; Experimental Animal Pathology Lab, University of Wisconsin-Madison, Madison, Wisconsin, USA., Graham M; Comparative Pathology Laboratory, Research Animal Resources and Compliance (RARC), University of Wisconsin-Madison, Madison, Wisconsin, USA., Casper EM; University of Wisconsin Hospitals and Clinics, UW Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Mitchell CC; Medicine/Division of Cardiovascular Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Varghese T; Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA. |
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Jazyk: | angličtina |
Zdroj: | Ultrasound in medicine & biology [Ultrasound Med Biol] 2023 Jan; Vol. 49 (1), pp. 45-61. Date of Electronic Publication: 2022 Sep 30. |
DOI: | 10.1016/j.ultrasmedbio.2022.07.012 |
Abstrakt: | Adaptive Bayesian regularized cardiac strain imaging (ABR-CSI) uses raw radiofrequency signals to estimate myocardial wall contractility as a surrogate measure of relative tissue elasticity incorporating regularization in the Bayesian sense. We determined the feasibility of using ABR-CSI -derived strain for in vivo longitudinal monitoring of cardiac remodeling in a murine ischemic injury model (myocardial infarction [MI] and ischemia-reperfusion [IR]) and validated the findings against ground truth histology. We randomly stratified 30 BALB/CJ mice (17 females, 13 males, median age = 10 wk) into three surgical groups (MI = 10, IR = 12, sham = 8) and imaged pre-surgery (baseline) and 1, 2, 7 and 14 d post-surgery using a pre-clinical high-frequency ultrasound system (VisualSonics Vevo 2100). We then used ABR-CSI to estimate end-systolic and peak radial (e (Copyright © 2022 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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