Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium.

Autor: Møller P; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, 0379, Oslo, Norway. moller.pal@gmail.com., Seppälä T; Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.; Applied Tumour Genomics Research Program, University of Helsinki, Helsinki, Finland.; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland., Dowty JG; Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, 3010, Australia., Haupt S; Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany.; Data Mining and Uncertainty Quantification (DMQ), Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany., Dominguez-Valentin M; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, 0379, Oslo, Norway., Sunde L; Department of Clinical Genetics, Aalborg University Hospital, 9000, Aalborg, Denmark.; Department of Biomedicine, Aarhus University, DK-8000, Aarhus, Denmark., Bernstein I; Department of Surgical Gastroenterology, Aalborg University Hospital, Aalborg University, 9100, Aalborg, Denmark.; Institute of Clinical Medicine, Aalborg University Hospital, Aalborg University, 9100, Aalborg, Denmark., Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107, Leipzig, Germany., Aretz S; Institute of Human Genetics, National Center for Hereditary Tumor Syndromes, Medical Faculty, University of Bonn, 53127, Bonn, Germany., Nielsen M; Department of Clinical Genetics, Leids Universitair Medisch Centrum, 2300RC, Leiden, The Netherlands., Capella G; Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L; Hospitalet de Llobregat, 08908, Barcelona, Spain., Evans DG; Division of Evolution and Genomic Sciences, Manchester Centre for Genomic Medicine, University of Manchester, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK., Burn J; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK., Holinski-Feder E; Campus Innenstadt, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, 80336, Munich, Germany.; MGZ - Center of Medical Genetics, 80335, Munich, Germany., Bertario L; Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology, IRCCS, 20141, Milan, Italy., Bonanni B; Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology, IRCCS, 20141, Milan, Italy., Lindblom A; Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden., Levi Z; Department Rabin Medical Center, Service High Risk GI Cancer Gastroenterology, Petach Tikva, Israel., Macrae F; Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia.; Department of Medicine, Melbourne University, Melbourne, Australia., Winship I; Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia.; Department of Medicine, Melbourne University, Melbourne, Australia., Plazzer JP; The Royal Melbourne Hospital, Melbourne, Australia., Sijmons R; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Laghi L; Department of Medicine and Surgery, Laboratory of Molecular Gastroenterology, IRCCS Humanitas Research Hospital, University of Parma, Parma, Italy., Valle AD; Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay., Heinimann K; Medical Genetics, Institute for Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Half E; Gastrointestinal Cancer Prevention Unit, Gastroenterology Department, Rambam Health Care Campus, Haifa, Israel., Lopez-Koestner F; Programa Cáncer Heredo Familiar Clínica Universidad de los Ande, Santiago, Chile., Alvarez-Valenzuela K; Programa Cáncer Heredo Familiar Clínica Universidad de los Ande, Santiago, Chile., Scott RJ; University of Newcastle and the Hunter Medical Research Institute, Callaghan, Australia., Katz L; Department of Gastroenterology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Laish I; The Department of Gastroenterology, High Risk and GI Cancer Prevention Clinic, Gastro-Oncology Unit, Sheba Medical Center, Ramat Gan, Israel., Vainer E; Department of Gastroenterology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Vaccaro CA; Hereditary Cancer Program (PROCANHE), Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina., Carraro DM; Genomic and Molecular Biology Group, A.C.Camargo Cancer Center, Sao Paulo, Brazil., Gluck N; Department of Gastroenterology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Abu-Freha N; The Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel., Stakelum A; St Vincent's University Hospital, Elm Park, Dublin 4, Ireland., Kennelly R; St Vincent's University Hospital, Elm Park, Dublin 4, Ireland., Winter D; St Vincent's University Hospital, Elm Park, Dublin 4, Ireland., Rossi BM; Hospital Sirio Libanes, Sao Paulo, Brazil., Greenblatt M; University of Vermont, Larner College of Medicine, Burlington, VT, 05405, USA., Bohorquez M; University of Tolima, Tolima, Colombia., Sheth H; Foundation for Research in Genetics and Endocrinology, FRIGE House, Jodhpur Village Road, Satellite Ahmedabad, Ahmedabad, 380015, India., Tibiletti MG; Ospedale di Circolo ASST Settelaghi, Centro di Ricerca Tumori Eredo-Familiari, Università dell'Insubria, Varese, Italy., Lino-Silva LS; Instituto Nacional de Cancerologia, Mexico, DF, Mexico., Horisberger K; Department of Abdominal and Transplantation Surgery, Universitätsspital Zürich, Rämistrasse 100, CH-8091, Zürich, Switzerland., Portenkirchner C; Department of Abdominal and Transplantation Surgery, Universitätsspital Zürich, Rämistrasse 100, CH-8091, Zürich, Switzerland., Nascimento I; Laboratório de Imonologia, ICS/UFBA, Núcleo de Oncologia da Bahia/Oncoclinicas, Salvador, Brazil., Rossi NT; Hospital Privado Universitario de Córdoba, Cordoba, Argentina., da Silva LA; Hospital Universitario Oswaldo Cruz, Universidade de Pernambuco, Hospital de Câncer de Pernambuco, IPON - Instituto de Pesquisas Oncológicas do Nordeste, Salvador, Brazil., Thomas H; Department of Surgery and Cancer, St Mark's Hospital, Imperial College London, London, UK., Zaránd A; Department of Transplantation and Surgery, Semmelweis University Budapest, Budapest, Hungary., Mecklin JP; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.; Department of Surgery, Central Finland Health Care District, Jyväskylä, Finland., Pylvänäinen K; Department of Education and Science, Central Finland Health Care District, Jyväskylä, Finland., Renkonen-Sinisalo L; Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.; Applied Tumour Genomics Research Program, University of Helsinki, Helsinki, Finland., Lepisto A; Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.; Applied Tumour Genomics Research Program, University of Helsinki, Helsinki, Finland., Peltomäki P; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland., Therkildsen C; The Danish HNPCC Register, Gastro Unit, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark., Lindberg LJ; The Danish HNPCC Register, Gastro Unit, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark., Thorlacius-Ussing O; Department of Surgical Gastroenterology, Aalborg University Hospital, Aalborg University, 9100, Aalborg, Denmark.; Institute of Clinical Medicine, Aalborg University Hospital, Aalborg University, 9100, Aalborg, Denmark., von Knebel Doeberitz M; Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Applied Tumour Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Rahner N; Institute of Human Genetics, University Clinic Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany., Steinke-Lange V; Campus Innenstadt, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, 80336, Munich, Germany.; MGZ - Center of Medical Genetics, 80335, Munich, Germany., Schmiegel W; Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany., Vangala D; Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany., Perne C; Institute of Human Genetics, National Center for Hereditary Tumor Syndromes, Medical Faculty, University of Bonn, 53127, Bonn, Germany., Hüneburg R; Department of Internal Medicine, University Hospital Bonn, Bonn, Germany., de Vargas AF; Genetics Unit, Hospital Vargas de Caracas, Caracas, Venezuela.; Escuela de Medicina Jose Maria Vargas, Universidad, Central de Venezuela, UCV, Caracas, Venezuela., Latchford A; St Mark's Hospital, London, UK., Gerdes AM; Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, DK-2100, Copenhagen, Denmark., Backman AS; Department of Medicine Solna, Unit of Internal medicine, Karolinska Institutet, Stockholm, Sweden., Guillén-Ponce C; Medical Oncology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain., Snyder C; Hereditary Cancer Center, Department of Preventive Medicine, Creighton University, Omaha, NE, 68178, USA., Lautrup CK; Department of Clinical Genetics, Aalborg University Hospital, 9000, Aalborg, Denmark., Amor D; Murdoch Children's Research Institute and University of Melbourne Department of Paediatrics, Royal Children's Hospital, Parkville, VIC, 3052, Australia., Palmero E; Department of Genetics, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Stoffel E; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Duijkers F; Department of Clinical Genetics, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands., Hall MJ; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA., Hampel H; Division of Human Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA., Williams H; Department of Urology, Geisinger Medical Center, Danville, PA, 17822, USA., Okkels H; Department of Molecular Diagnostics, Aalborg University, Aalborg, Denmark., Lubiński J; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, Szczecin, Poland., Reece J; Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, 3010, Australia., Ngeow J; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore and Cancer Genetics Service National Cancer Centre Singapore, Singapore, Singapore., Guillem JG; Gastrointestinal Surgery, University of North Carolina, Chapel Hill, NC, USA., Arnold J; New Zealand Familial Gastrointestinal Cancer Service, Auckland, New Zealand., Wadt K; Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, DK-2100, Copenhagen, Denmark., Monahan K; St Mark's Hospital & Imperial College, London, UK., Senter L; Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA., Rasmussen LJ; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark., van Hest LP; Department of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Ricciardiello L; IRCCS AOU di Bologna, and Department of Medical and Surgical Sciences - University of Bologna, Bologna, Italy., Kohonen-Corish MRJ; Woolcock Institute of Medical Research, Glebe, Sydney, NSW, 2037, Australia., Ligtenberg MJL; Department of Human Genetics and Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands., Southey M; Monash Health Translation Precinct, Monash University, Clayton South, VIC, 3169, Australia., Aronson M; Zane Cohen Centre, Sinai Health System, Toronto, Ontario, Canada., Zahary MN; Faculty of Health Sciences, University Sultan Zainal Abidin, Kuala Terengganu, Terengganu, Malaysia., Samadder NJ; Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, AZ, 85054, USA., Poplawski N; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5000, Australia.; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, 5000, Australia., Hoogerbrugge N; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Morrison PJ; Regional Medical Genetics Centre, Belfast HSC Trust, City Hospital Campus, Queen's University Belfast, Belfast, Northern Ireland, UK., James P; Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, 3010, Australia., Lee G; Genomics Platform Group, Centre for Cancer Research, University of Melbourne, Parkville, VIC, Australia., Chen-Shtoyerman R; The Biology Department, Ariel University, Ariel and the Oncogenetic Clinic, The Clinical Genetics Institute, Kaplan Medical Center, Rehovot, Israel., Ankathil R; Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia., Pai R; Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA., Ward R; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, 2006, Australia., Parry S; New Zealand Familial Gastrointestinal Cancer Service, Auckland, New Zealand., Dębniak T; Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, Szczecin, Poland., John T; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., van Overeem Hansen T; Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, DK-2100, Copenhagen, Denmark., Caldés T; Molecular Oncology Laboratory, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Yamaguchi T; Department of Clinical Genetics, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan., Barca-Tierno V; Department of Genetics, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain., Garre P; Molecular Oncology Laboratory, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Cavestro GM; Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy., Weitz J; Technische Universität Dresden, Dresden, Germany., Redler S; Institute of Human Genetics, University Clinic Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany., Büttner R; Department of Pathology, University Hospital of Cologne, Cologne, Germany., Heuveline V; Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany., Hopper JL; Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, 3010, Australia., Win AK; Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, 3010, Australia., Lindor N; Department of Health Science Research, Mayo Clinic Arizona, Phoenix, USA., Gallinger S; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada., Le Marchand L; University of Hawaii Cancer Center, Honolulu, USA., Newcomb PA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA., Figueiredo J; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA., Buchanan DD; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia., Thibodeau SN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA., Ten Broeke SW; Leids Universitair Medisch Centrum, Leiden, Netherlands., Hovig E; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, 0379, Oslo, Norway.; Department of Informatics, Centre for Bioinformatics, University of Oslo, Oslo, Norway., Nakken S; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, 0379, Oslo, Norway.; Centre for Cancer Cell Reprogramming (CanCell), Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Pineda M; Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L; Hospitalet de Llobregat, 08908, Barcelona, Spain., Dueñas N; Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L; Hospitalet de Llobregat, 08908, Barcelona, Spain., Brunet J; Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L; Hospitalet de Llobregat, 08908, Barcelona, Spain., Green K; Division of Evolution and Genomic Sciences, Manchester Centre for Genomic Medicine, University of Manchester, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK., Lalloo F; Division of Evolution and Genomic Sciences, Manchester Centre for Genomic Medicine, University of Manchester, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK., Newton K; Department of Surgery, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester, Manchester, UK., Crosbie EJ; Gynaecological Oncology Research Group, Manchester University NHS Foundation Trust, Manchester, UK.; Division of Cancer Sciences, University of Manchester, Manchester, UK., Mints M; Division of Obstetrics and Gyneacology, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden., Tjandra D; Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia.; Department of Medicine, Melbourne University, Melbourne, Australia., Neffa F; Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay., Esperon P; Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay., Kariv R; Department of Gastroenterology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Rosner G; Department of Gastroenterology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Pavicic WH; Hereditary Cancer Program (PROCANHE), Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.; Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB), Hospital Italiano de Buenos Aires-IUHI-CONICET, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina., Kalfayan P; Hereditary Cancer Program (PROCANHE), Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina., Torrezan GT; Genomic and Molecular Biology Group, A.C.Camargo Cancer Center, Sao Paulo, Brazil., Bassaneze T; Hospital Sirio Libanes, Sao Paulo, Brazil., Martin C; Hospital Universitario Oswaldo Cruz, Universidade de Pernambuco, Hospital de Câncer de Pernambuco, IPON - Instituto de Pesquisas Oncológicas do Nordeste, Salvador, Brazil., Moslein G; Surgical Center for Hereditary Tumors, Ev. Bethesda Khs Duisburg, University Witten-Herdecke, Herdecke, Germany., Ahadova A; Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Kloor M; Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Sampson JR; Division of Cancer and Genetics, Institute of Medical Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK., Jenkins MA; Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, 3010, Australia.
Jazyk: angličtina
Zdroj: Hereditary cancer in clinical practice [Hered Cancer Clin Pract] 2022 Oct 01; Vol. 20 (1), pp. 36. Date of Electronic Publication: 2022 Oct 01.
DOI: 10.1186/s13053-022-00241-1
Abstrakt: Objective: To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants.
Methods: CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with polypectomy when polyps were identified. Comparison was made with a retrospective cohort reported by the International Mismatch Repair Consortium (IMRC). This comprised confirmed and inferred path_MMR carriers who were first- or second-degree relatives of Lynch syndrome probands.
Results: In the PLSD, 8,153 subjects had follow-up colonoscopy surveillance for a total of 67,604 years and 578 carriers had CRC diagnosed. Average cumulative incidences of CRC in path_MLH1 carriers at 70 years of age were 52% in males and 41% in females; for path_MSH2 50% and 39%; for path_MSH6 13% and 17% and for path_PMS2 11% and 8%. In contrast, in the IMRC cohort, corresponding cumulative incidences were 40% and 27%; 34% and 23%; 16% and 8% and 7% and 6%. Comparing just the European carriers in the two series gave similar findings. Numbers in the PLSD series did not allow comparisons of carriers from other continents separately. Cumulative incidences at 25 years were < 1% in all retrospective groups.
Conclusions: Prospectively observed CRC incidences (PLSD) in path_MLH1 and path_MSH2 carriers undergoing colonoscopy surveillance and polypectomy were higher than in the retrospective (IMRC) series, and were not reduced in path_MSH6 carriers. These findings were the opposite to those expected. CRC point incidence before 50 years of age was reduced in path_PMS2 carriers subjected to colonoscopy, but not significantly so.
(© 2022. The Author(s).)
Databáze: MEDLINE
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