Vitamin A deficiency during the perinatal period induces changes in vitamin A metabolism in the offspring. The regulation of intestinal vitamin A metabolism via ISX occurs only in male rats severely vitamin A-deficient.

Autor: Borel P; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France. Patrick.Borel@univ-amu.fr., Troadec R; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France., Damiani M; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France., Halimi C; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France., Nowicki M; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France., Guichard P; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France., Couturier C; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France., Margier M; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France., Mounien L; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France., Grino M; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France., Reboul E; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France., Landrier JF; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France., Desmarchelier C; Center for CardioVascular and Nutrition Research (C2VN), Faculté de Médecine, INRAE, INSERM, Aix Marseille Univ, 27, boulevard Jean Moulin, 13005, Marseille, France.; Institut Universitaire de France (IUF), Marseille, France.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2023 Mar; Vol. 62 (2), pp. 633-646. Date of Electronic Publication: 2022 Sep 30.
DOI: 10.1007/s00394-022-03019-2
Abstrakt: Purpose: 1) To test the hypothesis of the existence of a perinatal vitamin A (VA) programming of VA metabolism and to better understand the intestinal regulation of VA metabolism.
Methods: Offspring from rats reared on a control (C) or a VA-deficient (D) diet from 6 weeks before mating until offspring weaning, i.e., 7 weeks after mating, were themselves reared on a C or D diet for 19 weeks, resulting in the following groups: C-C (parents fed C-offspring fed C), D-C, C-D and D-D. VA concentrations were measured in plasma and liver. β-Carotene bioavailability and its intestinal conversion rate to VA, as well as vitamin D and E bioavailability, were assessed after gavages with these vitamins. Expression of genes involved in VA metabolism and transport was measured in intestine and liver.
Results: C-D and D-D had no detectable retinyl esters in their liver. Retinolemia, hepatic retinol concentrations and postprandial plasma retinol response to β-carotene gavage were higher in D-C than in C-C. Intestinal expression of Isx was abolished in C-D and D-D and this was concomitant with a higher expression of Bco1, Scarb1, Cd36 and Lrat in males receiving a D diet as compared to those receiving a C diet. β-Carotene, vitamin D and E bio-availabilities were lower in offspring receiving a D diet as compared to those receiving a C diet.
Conclusion: A VA-deficient diet during the perinatal period modifies the metabolism of this vitamin in the offspring. Isx-mediated regulation of Bco1 and Scarb1 expression exists only in males severely deficient in this vitamin. Severe VA deficiency impairs β-carotene and vitamin D and E bioavailability.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
Databáze: MEDLINE
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