Enuresis and upper airway obstruction: BNP and ADH hormones behavior before and after airway surgery.

Autor:	Ribeiro A; Divisão de Otorrinolaringologia, Departamento de Cirurgia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil., Bastos JM Netto; Divisão de Urologia, Departamento de Cirurgia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.; Divisão de Urologia, Departamento de Cirurgia, Hospital e Maternidade Therezinha de Jesus da Faculdade de Ciências Médicas e da Saúde de Juiz de Fora (HMTJ/Suprema) Juiz de Fora, MG, Brasil., de Figueiredo AA; Divisão de Urologia, Departamento de Cirurgia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil., Cândido TC; Divisão de Otorrinolaringologia, Departamento de Cirurgia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil., Guércio WB; Divisão de Otorrinolaringologia, Departamento de Cirurgia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil., Zica BO; Divisão de Urologia, Departamento de Cirurgia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
Jazyk:	angličtina
Zdroj:	International braz j urol : official journal of the Brazilian Society of Urology [Int Braz J Urol] 2022 Nov-Dec; Vol. 48 (6), pp. 937-943.
DOI:	10.1590/S1677-5538.IBJU.2022.0313
Abstrakt:	Introduction: Upper airway obstruction (UAO) is a common condition in all pediatric population, with a 27% prevalence. Primary monosymptomatic nocturnal enuresis (PMNE) is a condition related to UAO in 8% to 47% of these children. The specific pathophysiological mechanism of this bond is not well understood. Some authors suggest a connection between brain natrituretic peptide (BNP) and anti-diuretic hormone (ADH) during sleep. The aim of this study was to evaluate hormone profile (ADH and BNP) and improvement in dry nights in a sample of children before and after surgical treatment of the UAO. Methods: This is a longitudinal prospective interventionist study in children, 5 to 14 years of age, with UAO and PMNE recruited in a specialty outpatient clinic. Children presenting UAO and PMNE were evaluated with a 30-day dry night diary and blood samples were collected to evaluate ADH and BNP before and after upper airway surgery. Data were analyzed prior to surgery and 90-120 days after surgery. Results: Twenty-one children with a mean age of 9.7 years were included. Mean BNP before surgery was 116.5 ± 126.5 pg/mL and 156.2 ± 112.3 pg/mL after surgery (p<0.01). Mean ADH was 5.8 ± 3.2 pg/mL and 14.6 ± 35.4 before and after surgery, respectively (p=0.26). The percentage of dry nights went from 32.3 ± 24.7 before surgery to 75.4 ± 33.4 after surgery (p˂0.01). Conclusion: Surgery for airway obstruction contributed to an increase in BNP without increasing ADH. A total of 85.8% of the children presented partial or complete improvement of their enuresis. Competing Interests: None declared. (Copyright® by the International Brazilian Journal of Urology.)
Databáze:	MEDLINE
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