Clinico-epidemiological and sociodemographic profile of patients with hemophilia in the Brazilian Amazon: High prevalence of hepatitis C infection and its possible corrrelation with inhibitor development.

Autor:	Santos EM; Programa de Pós-Graduação em Hematologia, Universidade Do Estado Do Amazonas (UEA), Manaus, Amazonas, Brazil., Silva JM; Programa de Pós-Graduação em Imunologia Básica e Aplicada-PPGIBA, Instituto de Ciências Biológicas, Universidade Federal Do Amazonas-UFAM, Manaus, Amazonas, Brazil., Barbosa AN; Laboratório de Virologia e e Imunologia, Institituto Nacional de Pesquisa da Amazônia (INPA), Manaus, Amazonas, Brazil., Pontes GS; Programa de Pós-Graduação em Hematologia, Universidade Do Estado Do Amazonas (UEA), Manaus, Amazonas, Brazil.; Programa de Pós-Graduação em Imunologia Básica e Aplicada-PPGIBA, Instituto de Ciências Biológicas, Universidade Federal Do Amazonas-UFAM, Manaus, Amazonas, Brazil.; Laboratório de Virologia e e Imunologia, Institituto Nacional de Pesquisa da Amazônia (INPA), Manaus, Amazonas, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2022 Sep 08; Vol. 10, pp. 963790. Date of Electronic Publication: 2022 Sep 08 (Print Publication: 2022).
DOI:	10.3389/fpubh.2022.963790
Abstrakt:	Hemophilia is a recessive genetic disease caused by a mutation on the X chromosome that has been linked to a high risk of transfusion - transmitted infections, especially sexually transmitted infections. The purpose of this retrospective study was to characterize the clinical and epidemiological profile and describe the prevalence of sexually transmitted viral infections in patients with hemophilia in the Northern Brazilian state of Amazonas. We assessed clinical, laboratory and sociodemographic data of hemophiliac patients ( n = 311) for the period 2011-2019. The majority of the study population was composed of people with a low level of education aged 21-30 years old. The prevalence of HCV, HBV, and HTLV-1/2 infections among the study population were 10.52, 0.52, and 1.05%, respectively. No HIV infection was found among the patients. Between 2011 and 2015 the prevalence of HCV increased by over 100% and the incidence peaked in 2013. The severe hemophilia was associated with the presence of inhibitor factor (Odds Ratio [OD] 9.83; 95% IC: 3.41-27.62, p < 0.0001) or target joint (OD 6.59; 95% IC: 3.27-13.34, p < 0.0001). The presence of inhibitor was positive and significantly correlated with HCV infection ( r = 1.00, p < 0.0001). Our results showed that HCV infection is highly prevalent in patients with hemophilia and might be involved in the development of inhibitors. Thus, these data provide new insights into the clinical and epidemiological profile of patients suffering from hemophilia in the Northern Brazilian state of Amazonas. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Santos, Silva, Barbosa and Pontes.)
Databáze:	MEDLINE
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