Tissue Engineering with Stem Cell from Human Exfoliated Deciduous Teeth (SHED) and Collagen Matrix, Regulated by Growth Factor in Regenerating the Dental Pulp.

Autor: Sugiaman VK; Department of Oral Biology, Faculty of Dentistry, Maranatha Christian University, Bandung 40164, Indonesia., Djuanda R; Department of Conservative Dentistry and Endodontic, Faculty of Dentistry, Maranatha Christian University, Bandung 40164, Indonesia., Pranata N; Department of Oral Biology, Faculty of Dentistry, Maranatha Christian University, Bandung 40164, Indonesia., Naliani S; Department of Prosthodontics, Faculty of Dentistry, Maranatha Christian University, Bandung 40164, Indonesia., Demolsky WL; Department of Oral Biology, Faculty of Dentistry, Maranatha Christian University, Bandung 40164, Indonesia., Jeffrey; Department of Pediatric Dentistry, Faculty of Dentistry, Jenderal Achmad Yani University, Cimahi 40531, Indonesia.
Jazyk: angličtina
Zdroj: Polymers [Polymers (Basel)] 2022 Sep 06; Vol. 14 (18). Date of Electronic Publication: 2022 Sep 06.
DOI: 10.3390/polym14183712
Abstrakt: Maintaining dental pulp vitality and preventing tooth loss are two challenges in endodontic treatment. A tooth lacking a viable pulp loses its defense mechanism and regenerative ability, making it more vulnerable to severe damage and eventually necessitating extraction. The tissue engineering approach has drawn attention as an alternative therapy as it can regenerate dentin-pulp complex structures and functions. Stem cells or progenitor cells, extracellular matrix, and signaling molecules are triad components of this approach. Stem cells from human exfoliated deciduous teeth (SHED) are a promising, noninvasive source of stem cells for tissue regeneration. Not only can SHEDs regenerate dentin-pulp tissues (comprised of fibroblasts, odontoblasts, endothelial cells, and nerve cells), but SHEDs also possess immunomodulatory and immunosuppressive properties. The collagen matrix is a material of choice to provide structural and microenvironmental support for SHED-to-dentin pulp tissue differentiation. Growth factors regulate cell proliferation, migration, and differentiation into specific phenotypes via signal-transduction pathways. This review provides current concepts and applications of the tissue engineering approach, especially SHEDs, in endodontic treatment.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje