Dynamics of Dopamine and Other Monoamines Content in Rat Brain after Single Low-Dose Carbon Nuclei Irradiation.

Autor: Kokhan VS; V.P. Serbsky Federal Medical Research Centre for Psychiatry and Narcology, 119034 Moscow, Russia., Ustyugov AA; Institute of Physiologically Active Compounds RAS, 142432 Chernogolovka, Russia., Pikalov VA; Institute for High Energy Physics Named by A.A. Logunov of National Research Centre 'Kurchatov Institute', 142281 Protvino, Russia.
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2022 Aug 25; Vol. 12 (9). Date of Electronic Publication: 2022 Aug 25.
DOI: 10.3390/life12091306
Abstrakt: Space radiation, presented primarily by high-charge and -energy particles (HZEs), has a substantial impact on the central nervous system (CNS) of astronauts. This impact, surprisingly, has not only negative but also positive effects on CNS functions. Despite the fact that the mechanisms of this effect have not yet been elucidated, several studies indicate a key role for monoaminergic networks underlying these effects. Here, we investigated the effects of acute irradiation with 450 MeV/n carbon ( 12 C) nuclei at a dose of 0.14 Gy on Wistar rats; a state of anxiety was accessed using a light-dark box, spatial memory in a Morris water maze, and the dynamics of monoamine metabolism in several brain morphological structures using HPLC. No behavioral changes were observed. Irradiation led to the immediate suppression of dopamine turnover in the prefrontal cortex, hypothalamus, and striatum, while a decrease in the level of norepinephrine was detected in the amygdala. However, these effects were transient. The deferred effect of dopamine turnover increase was found in the hippocampus. These data underscore the ability of even low-dose 12 C irradiation to affect monoaminergic networks. However, this impact is transient and is not accompanied by behavioral alterations.
Databáze: MEDLINE
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