Copy Number Variants in Two Northernmost Cattle Breeds Are Related to Their Adaptive Phenotypes.
| Autor: | Buggiotti L; Royal Veterinary College, University of London, London NW1 0TU, UK., Yudin NS; The Federal State Budgetary Institution of Science Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences (ICG SB RAS), Novosibirsk 630090, Russia.; Kurchatov Genomics Center, the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science (ICG SB RAS), Novosibirsk 630090, Russia., Larkin DM; Royal Veterinary College, University of London, London NW1 0TU, UK. |
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| Jazyk: | angličtina |
| Zdroj: | Genes [Genes (Basel)] 2022 Sep 06; Vol. 13 (9). Date of Electronic Publication: 2022 Sep 06. |
| DOI: | 10.3390/genes13091595 |
| Abstrakt: | Copy number variations (CNVs) are genomic structural variants with potential functional and evolutionary effects on phenotypes. In this study, we report the identification and characterization of CNVs from the whole-genome resequencing data of two northernmost cattle breeds from Russia: the Yakut and Kholmogory cattle and their phylogenetically most related breeds, Hanwoo and Holstein, respectively. Comparisons of the CNV regions (CNVRs) among the breeds led to the identification of breed-specific CNVRs shared by cold-adapted Kholmogory and Yakut cattle. An investigation of their overlap with genes, regulatory domains, conserved non-coding elements (CNEs), enhancers, and quantitative trait loci (QTLs) was performed to further explore breed-specific biology and adaptations. We found CNVRs enriched for gene ontology terms related to adaptation to environments in both the Kholmogory and Yakut breeds and related to thermoregulation specifically in Yakut cattle. Interestingly, the latter has also been supported when exploring the enrichment of breed-specific CNVRs in the regulatory domains and enhancers, CNEs, and QTLs implying the potential contribution of CNVR to the Yakut and Kholmogory cattle breeds' adaptation to a harsh environment. Competing Interests: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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