Circulating Angiogenic Markers in Gastroenteropancreatic Neuroendocrine Neoplasms: A Systematic Review.

Autor:	Sandra I; Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 020022 Bucharest, Romania.; Department of Oncology, Fundeni Clinical Institute, 022328 Bucharest, Romania., Cazacu IM; Department of Oncology, Fundeni Clinical Institute, 022328 Bucharest, Romania.; Faculty of Medicine, 'Titu Maiorescu' University of Medicine and Pharmacy, 020022 Bucharest, Romania., Croitoru VM; Department of Oncology, Fundeni Clinical Institute, 022328 Bucharest, Romania.; Faculty of Medicine, 'Titu Maiorescu' University of Medicine and Pharmacy, 020022 Bucharest, Romania., Mihaila M; Department of Internal Medicine, Fundeni Clinical Institute, 022328 Bucharest, Romania., Herlea V; Faculty of Medicine, 'Titu Maiorescu' University of Medicine and Pharmacy, 020022 Bucharest, Romania.; Department of Pathology, Fundeni Clinical Institute, 022328 Bucharest, Romania., Diculescu MM; Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 020022 Bucharest, Romania.; Department of Gastroenterology and Hepatology, Fundeni Clinical Institute, 022328 Bucharest, Romania., Dima SO; Faculty of Medicine, 'Titu Maiorescu' University of Medicine and Pharmacy, 020022 Bucharest, Romania.; Department of General Surgery, Fundeni Clinical Institute, 022328 Bucharest, Romania.; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328 Bucharest, Romania., Croitoru AE; Department of Oncology, Fundeni Clinical Institute, 022328 Bucharest, Romania.; Faculty of Medicine, 'Titu Maiorescu' University of Medicine and Pharmacy, 020022 Bucharest, Romania.
Jazyk:	angličtina
Zdroj:	Current issues in molecular biology [Curr Issues Mol Biol] 2022 Sep 04; Vol. 44 (9), pp. 4001-4014. Date of Electronic Publication: 2022 Sep 04.
DOI:	10.3390/cimb44090274
Abstrakt:	Background: Neuroendocrine neoplasms are a heterogeneous group of tumors that raise challenges in terms of diagnosis, treatment and monitoring. Despite continuous efforts, no biomarker has showed satisfying accuracy in predicting outcome or response to treatment. Methods: We conducted a systematic review to determine relevant circulating biomarkers for angiogenesis in neuroendocrine tumors. We searched three databases (Pubmed, Embase, Web of Science) using the keywords "neuroendocrine" and "biomarkers", plus specific biomarkers were searched by full and abbreviated name. From a total of 2448 publications, 11 articles met the eligibility criteria. Results: VEGF is the most potent and the most studied angiogenic molecule, but results were highly controversial. Placental growth factor, Angiopoietin 2 and IL-8 were the most consistent markers in predicting poor outcome and aggressive disease behavior. Conclusions: There is no robust evidence so far to sustain the use of angiogenic biomarkers in routine practice, although the results show promising leads.
Databáze:	MEDLINE
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