[Prospective noninterventional BLUE SKY study evaluating the efficacy of brolucizumab in treatment-naïve and previously treated patients with neovascular AMD].

Autor: Faatz H; Augenzentrum am St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Deutschland., Feltgen N; Universitätsaugenklinik Göttingen, Göttingen, Deutschland., Gutfleisch M; Augenzentrum am St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Deutschland., Heimes-Bussmann B; Augenzentrum am St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Deutschland., Krohne TU; Universitätsaugenklinik Köln, Köln, Deutschland., Liakopoulos S; Universitätsaugenklinik Köln, Köln, Deutschland.; Universitätsaugenklinik Frankfurt, Frankfurt, Deutschland., Liegl R; Universitätsaugenklinik Bonn, Bonn, Deutschland., Lommatzsch A; Augenzentrum am St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Deutschland., Mussinghoff P; Augenzentrum am St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Deutschland., Rehak M; Universitätsaugenklinik Gießen, Gießen, Deutschland., Schmitz-Valckenberg S; Universitätsaugenklinik Bonn, Bonn, Deutschland.; John A. Moran Eye Center, University of Utah, Salt Lake City, USA., Spital G; Augenzentrum am St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Deutschland., Stanzel B; Augenklinik Sulzbach, Sulzbach, Deutschland., Ziemssen F; Universitätsaugenklinik Leipzig, Leipzig, Deutschland., Hägele B; Novartis Pharma GmbH, Nürnberg, Deutschland., Junkes C; Novartis Pharma GmbH, Nürnberg, Deutschland., Porstner M; Novartis Pharma GmbH, Nürnberg, Deutschland., Vögeler J; Novartis Pharma GmbH, Nürnberg, Deutschland., Gmeiner B; Novartis Pharma GmbH, Nürnberg, Deutschland., Pauleikhoff D; Augenzentrum am St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Deutschland. dapauleikhoff@muenster.de.
Jazyk: němčina
Zdroj: Die Ophthalmologie [Ophthalmologie] 2023 Mar; Vol. 120 (3), pp. 294-300. Date of Electronic Publication: 2022 Sep 20.
DOI: 10.1007/s00347-022-01731-2
Abstrakt: Intravitreal injection of anti-vascular endothelial growth factor (VEGF) is the standard treatment for patients with neovascular age-related macular degeneration (nAMD). In addition to the approved substances ranibizumab (Lucentis®, Novartis) and aflibercept (Eylea®, Bayer), bevacizumab (Avastin®, Roche) is also available. Furthermore, brolucizumab (Beovu®, Novartis) has been approved and has been available in Germany since April 2020. The multicenter, noninterventional prospective BLUE SKY study investigates brolucizumab treatment with different schemes in 600 treatment-naive and pretreated nAMD patients in routine clinical practice over a 24-month period. Besides general patient data, visual acuity and treatment data will be documented. Fluorescein angiography, fundus photography, spectral domain optical coherence tomography and swept-source optical coherence tomography angiography will be performed and analyzed by reading centers. The focus of the analysis will be on the intraretinal and subretinal fluid distribution as well as morphological MNV changes and injection frequency. Also, safety and adverse drug effects of brolucizumab, with a specific focus on inflammatory complications, particularly retinal (occlusive) vasculitis will be evaluated.
(© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
Databáze: MEDLINE
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