A field guide to Aurora kinase inhibitors: an oocyte perspective.
| Autor: | Blengini CS; Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.; Human Genetics Institute of New Jersey, Piscataway, New Jersey, USA., Ik Jung G; Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.; Human Genetics Institute of New Jersey, Piscataway, New Jersey, USA., Aboelenain M; Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.; Human Genetics Institute of New Jersey, Piscataway, New Jersey, USA.; Department of Theriogenology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt., Schindler K; Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.; Human Genetics Institute of New Jersey, Piscataway, New Jersey, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Reproduction (Cambridge, England) [Reproduction] 2022 Sep 20; Vol. 164 (4), pp. V5-V7. Date of Electronic Publication: 2022 Sep 20 (Print Publication: 2022). |
| DOI: | 10.1530/REP-22-0292 |
| Abstrakt: | In Brief: The Aurora protein kinases have critical functions in controlling oocyte meiotic maturation. In this study, we describe an assay for examining their activation state in oocytes and establish the best working doses of three commonly used inhibitors. Abstract: Several small molecule inhibitors exist for targeting Aurora kinase proteins in somatic cells. From this point of view, we evaluate the specificity of these inhibitors in mouse oocytes, and we demonstrate that MLN 8237 and AZD 1152 are specific for Aurora kinase A and Aurora kinase C, respectively, only when used at low concentrations. |
| Databáze: | MEDLINE |
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