Design consideration of a novel polymeric transcatheter heart valve through computational modeling.

Autor: Bui HT; Department of Biomedical Engineering, Georgia Institute of Technology, 387 Technology Cir NW, Atlanta, GA, 30313, USA., Ishrat A; Department of Biomedical Engineering, Georgia Institute of Technology, 387 Technology Cir NW, Atlanta, GA, 30313, USA., James SP; School of Advanced Materials Discovery, Colorado State University, 700 Meridian Ave, Fort Collins, CO, 80523, USA., Dasi LP; Department of Biomedical Engineering, Georgia Institute of Technology, 387 Technology Cir NW, Atlanta, GA, 30313, USA. Electronic address: lakshmi.dasi@gatech.edu.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2022 Nov; Vol. 135, pp. 105434. Date of Electronic Publication: 2022 Sep 12.
DOI: 10.1016/j.jmbbm.2022.105434
Abstrakt: Transcatheter heart valve replacement is becoming a more routine procedure, and this is further supported by positive outcomes from studies involving low-risk patients. Nevertheless, the lack of long-term transcatheter heart valve (TAV) durability is still one of the primary concerns. As a result, more research has been focused on improving durability through various methods such as valve design, computational modeling, and material selection. Recent advancements in polymeric valve fabrication showed that linear low-density polyethylene (LLDPE) could be used as leaflet material for transcatheter heart valves. In this paper, a parametric study of computational simulations showed stress distribution on the leaflets of LLDPE-TAV under diastolic load, and the results were used to improve the stent design. The in silico experiment also tested the effect of shock absorbers in terms of valve durability. The results demonstrated that altering specific stent angles can significantly lower peak stress on the leaflets (13.8 vs. 6.07 MPa). Implementing two layers of shock absorbers further reduces the stress value to 4.28 MPa. The pinwheeling index was assessed, which seems to correlate with peak stress. Overall, the parametric study and the computational method can be used to analyze and improve valve durability.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Hieu Bui., Susan James., and Lakshmi Prasad Dasi have a patent for manufacturing blood compatible polymers. They also submitted invention disclosures for fabricating polymeric valved conduit and optimizing heart valve durability. Lakshmi Prasad Dasi holds patents for designing prosthetic heart valves and vortex generators on heart valves. Both Lakshmi Prasad Dasi and Susan James are co-founders of YoungHeartValve Inc. Hieu Bui is an employee of YoungHeartValve Inc.
(Copyright © 2022. Published by Elsevier Ltd.)
Databáze: MEDLINE
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