Systemic conditions associated with increased risk to develop oral squamous cell carcinoma: Systematic review and meta-analysis.

Autor: Dos Santos ES; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Pérez-de-Oliveira ME; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Normando AGC; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Gueiros LAM; Oral Medicine Unit, Departamento de Clínica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Brazil., Rogatto SR; Department of Clinical Genetics, University Hospital of Southern Denmark, Vejle and Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Vargas PA; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., Lopes MA; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil., da Silva Guerra EN; Laboratory of Oral Histopathology, School of Health Sciences, University of Brasília, Brasilia, Brazil., Leme AFP; Brazilian Bioscience National Laboratory, Brazil Center of Research in Energy and Materials, Campinas, Brazil., Santos-Silva AR; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2022 Dec; Vol. 44 (12), pp. 2925-2937. Date of Electronic Publication: 2022 Sep 16.
DOI: 10.1002/hed.27193
Abstrakt: This study aimed to map systemic alterations predisposing to oral squamous cell carcinoma (OSCC) onset. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Five databases were used to access (1) reports of OSCC co-occurring in patients with systemic conditions, (2) prevalence of OSCC among these patients, and (3) clinicopathological profiles. Data from more than 1 million patients worldwide showed that Fanconi's anemia, xeroderma pigmentosum, dyskeratosis congenital, chronic fatigue syndrome, and patients post bone marrow transplantation (BMT) present increased risk for OSCC development. The overall prevalence of OSCC in syndromic patients and post-BMT were 0.65% (95% CI = 0.13-3.11, p < 0.01) and 5.83% (95% CI = 0.00-30.90, p < 0.01), respectively. The certainty of the evidence was moderate. This study demonstrated that some systemic conditions predispose to OSCC. These results present an impact on the screening of OSCC in systemically compromised patients.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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