Structural investigation of sulfobetaines and phospholipid monolayers at the air-water interface.

Autor:	Elstone N; Centre for Sustainable & Circular Technologies, University of Bath, Claverton Down, Bath, BA2 7AY, UK. Naomi.Elstone@york.ac.uk.; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK., Arnold T; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.; European Spallation Source ERIC, P.O. Box 176, SE-221 00 Lund, Sweden.; Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.; ISIS Neutron Source Facility, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK., Skoda MWA; ISIS Neutron Source Facility, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK., Lewis SE; Centre for Sustainable & Circular Technologies, University of Bath, Claverton Down, Bath, BA2 7AY, UK. Naomi.Elstone@york.ac.uk.; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK., Li P; ISIS Neutron Source Facility, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK., Hazell G; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK., Edler KJ; Centre for Sustainable & Circular Technologies, University of Bath, Claverton Down, Bath, BA2 7AY, UK. Naomi.Elstone@york.ac.uk.; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Jazyk:	angličtina
Zdroj:	Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2022 Sep 28; Vol. 24 (37), pp. 22679-22690. Date of Electronic Publication: 2022 Sep 28.
DOI:	10.1039/d2cp02695c
Abstrakt:	Mixtures of sulfobetaine based lipids with phosphocholine phospholipids are of interest in order to study the interactions between zwitterionic surfactants and the phospholipids present in cell membranes. In this study we have investigated the structure of mixed monolayers of sulfobetaines and phosphocholine phospholipids. The sulfobetaine used has a single 18-carbon tail, and is referred to as SB3-18, and the phospholipid used is DMPC. Surface pressure-area isotherms of the samples were used to determine whether any phase transitions were present during the compression of the monolayers. Neutron and X-ray reflectometry were then used to investigate the structure of these monolayers perpendicular to the interface. We found that the average headgroup and tail layer thickness was reasonably consistent across all mixtures, with a variation of less than 3 Å reported in the total thickness of the monolayers at each surface pressure. However, by selective deuteration of the two components of the monolayers, it was found that the two components have different tail layer thicknesses. For the mixture with equal compositions of DMPC and SB3-18 or with a higher composition of DMPC the tail tilts were found to be constant, resulting in a greater tail layer thickness for SB3-18 due to its longer tail. For the mixture higher in SB3-18 this was not the case, the tail tilt angle for the two components was found to be different and DMPC was found to have a greater tail layer thickness than SB3-18 as a result.
Databáze:	MEDLINE
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