Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain.

Autor:	Tenza-Ferrer H; Centro de Tecnologia em Medicina Molecular, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Collodetti M; Centro de Tecnologia em Medicina Molecular, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Nicolau ES; Centro de Tecnologia em Medicina Molecular, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil., Birbrair A; Departamento de Patologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.; Department of Dermatology, University of Wisconsin-Madison, Madison, WI, United States.; Department of Radiology, Columbia University Medical Center, New York, NY, United States., Magno LAV; Centro de Tecnologia em Medicina Molecular, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.; Curso de Medicina, Universidade José do Rosário Vellano (UNIFENAS), Belo Horizonte, Brazil.; Pós-graduação da Faculdade Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil., Romano-Silva MA; Centro de Tecnologia em Medicina Molecular, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.; Departamento de Saúde Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular neuroscience [Front Cell Neurosci] 2022 Aug 29; Vol. 16, pp. 933874. Date of Electronic Publication: 2022 Aug 29 (Print Publication: 2022).
DOI:	10.3389/fncel.2022.933874
Abstrakt:	While current research highlights the role of Nav1. 8 sensory neurons from the peripheral nervous system, the anatomical and physiological characterization of encephalic Nav1.8 neurons remains unknown. Here, we use a Cre/fluorescent reporter mouse driven by the Nav1.8 gene promoter to reveal unexpected subpopulations of transiently-expressing Nav1.8 neurons within the limbic circuitry, a key mediator of the emotional component of pain. We observed that Nav1.8 neurons from the bed nuclei of the stria terminalis (BST), amygdala, and the periaqueductal gray (vPAG) are sensitive to noxious stimuli from an experimental model of chronic inflammatory pain. These findings identify a novel role for central Nav1.8 neurons in sensing nociception, which could be researched as a new approach to treating pain disorders. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Tenza-Ferrer, Collodetti, Nicolau, Birbrair, Magno and Romano-Silva.)
Databáze:	MEDLINE
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