Ex vivo efficacy of sonodynamic antimicrobial chemotherapy for inhibition of Enterococcus faecalis and Candida albicans biofilm.

Autor: Yasini Z; Department of Endodontics, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Roghanizad N; Department of Endodontics, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Fazlyab M; Department of Endodontics, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Iranian Center for Endodontic Research, Research Institute of Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Pourhajibagher M; Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: m-pourhajibagher@alumnus.tums.ac.ir.
Jazyk: angličtina
Zdroj: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2022 Dec; Vol. 40, pp. 103113. Date of Electronic Publication: 2022 Sep 10.
DOI: 10.1016/j.pdpdt.2022.103113
Abstrakt: Background: This study aimed to assess the ex vivo efficacy of sonodynamic antimicrobial chemotherapy (SACT) also known as antimicrobial sonodynamic therapy for inhibition of Enterococcus faecalis and Candida albicans biofilm.
Materials and Methods: This study was conducted on 80 extracted single-canal maxillary anterior teeth. After instrumentation, the root canals were inoculated with E. faecalis and C. albicans suspensions, and the teeth were assigned to 5 groups of control (no antimicrobial therapy), nano-curcumin, ultrasound waves, 5.25% sodium hypochlorite (NaOCl), and SACT (nano-curcumin plus ultrasound waves). The mean biofilm thickness and number of colonies were then counted.
Results: The E. faecalis colony count in nano-curcumin, ultrasound waves, and SACT groups was significantly lower than that in the control group (P<0.05). The C. albicans colony count in SACT group was significantly lower than that in the control and ultrasound waves groups (P<0.05). The mean biofilm thickness in NaOCl and SACT groups was significantly thinner than other groups (P<0.05). The mean biofilm thickness in SACT group was significantly thinner than that in ultrasound waves group (P<0.001).
Conclusion: In summary, SACT using nano-curcumin had an almost comparable efficacy to NaOCl, but was more effective than ultrasound waves and nano-curcumin for reduction of C. albicans and E. faecalis biofilm.
Competing Interests: Declaration Competing of Interest There is no competing interest.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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