Evasion of interferon-mediated immune response by arteriviruses.

Autor:	Jian Z; College of Veterinary Medicine, Sichuan Agricultural University, Cheng Du, China., Ma R; College of Veterinary Medicine, Sichuan Agricultural University, Cheng Du, China., Zhu L; College of Veterinary Medicine, Sichuan Agricultural University, Cheng Du, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Cheng Du, China., Deng H; College of Veterinary Medicine, Sichuan Agricultural University, Cheng Du, China., Li F; College of Veterinary Medicine, Sichuan Agricultural University, Cheng Du, China.; College of Animal Science, Xichang University, Xichang, China., Zhao J; College of Veterinary Medicine, Sichuan Agricultural University, Cheng Du, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Cheng Du, China., Deng L; College of Veterinary Medicine, Sichuan Agricultural University, Cheng Du, China., Lai S; College of Veterinary Medicine, Sichuan Agricultural University, Cheng Du, China., Sun X; College of Veterinary Medicine, Sichuan Agricultural University, Cheng Du, China., Tang H; College of Veterinary Medicine, Sichuan Agricultural University, Cheng Du, China., Xu Z; College of Veterinary Medicine, Sichuan Agricultural University, Cheng Du, China.; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Cheng Du, China.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2022 Aug 15; Vol. 13, pp. 963923. Date of Electronic Publication: 2022 Aug 15 (Print Publication: 2022).
DOI:	10.3389/fimmu.2022.963923
Abstrakt:	IFN is the most potent antiviral cytokine required for the innate and adaptive immune responses, and its expression can help the host defend against viral infection. Arteriviruses have evolved strategies to antagonize the host cell's innate immune responses, interfering with IFN expression by interfering with RIG, blocking PRR, obstructing IRF-3/7, NF-κB, and degrading STAT1 signaling pathways, thereby assisting viral immune evasion. Arteriviruses infect immune cells and may result in persistence in infected hosts. In this article, we reviewed the strategies used by Arteriviruses to antagonize IFN production and thwart IFN-activated antiviral signaling, mainly including structural and nonstructural proteins of Arteriviruses encoding IFN antagonists directly or indirectly to disrupt innate immunity. This review will certainly provide a better insight into the pathogenesis of the arthritis virus and provide a theoretical basis for developing more efficient vaccines. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Jian, Ma, Zhu, Deng, Li, Zhao, Deng, Lai, Sun, Tang and Xu.)
Databáze:	MEDLINE
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