Platelet-Rich Plasma Injections: Pharmacological and Clinical Considerations in Pain Management.

Autor: Grossen AA; Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 N Lincoln Blvd Suite 4000, Oklahoma City, OK, 73104, USA. audrey-grossen@ouhsc.edu., Lee BJ; Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 N Lincoln Blvd Suite 4000, Oklahoma City, OK, 73104, USA., Shi HH; Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 N Lincoln Blvd Suite 4000, Oklahoma City, OK, 73104, USA., Shakir HJ; Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 N Lincoln Blvd Suite 4000, Oklahoma City, OK, 73104, USA., Cornett EM; Department of Anesthesiology, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA., Kaye AD; LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71103, USA.
Jazyk: angličtina
Zdroj: Current pain and headache reports [Curr Pain Headache Rep] 2022 Oct; Vol. 26 (10), pp. 741-749. Date of Electronic Publication: 2022 Sep 10.
DOI: 10.1007/s11916-022-01082-2
Abstrakt: Purpose of Review: Regenerative medicine through interventional pain procedures is evolving with data demonstrating efficacy for a number of pain states in recent years. Platelet-rich plasma (PRP), defined as a sample of plasma with a platelet concentration 3 to 5 times greater than the physiologic platelet concentration found in healthy whole blood, releases bioactive proteins which can restore anatomical function in degenerative states. PRP is dense in growth factors, such as platelet-derived growth factor, transforming growth factor-beta1, basic fibroblastic growth factor, vascular endothelial growth factor, and epidermal growth factors.
Recent Findings: To date, well-designed case-control or cohort studies for the use of PRP have demonstrated efficacy in lumbar facet joint, lumbar epidural, and sacroiliac joint injections. At present, there is only level IV evidence indicating the need for larger and more carefully controlled prospective studies. PRP is utilized autogenously in order to facilitate healing and injection and has been studied in the long-term management of discogenic low back pain. In this regard, numerous studies have evaluated PRP to steroid injections in chronic pain states with favorable results. PRP represents an opportunity for a new strategy in the therapeutic treatment of degenerative states of spines, joints, and other locations throughout the body with evolving data demonstrating both safety and long-term efficacy.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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