Frequencies and Association of CYP3A5 Polymorphism With Tacrolimus Concentration Among Renal Transplant Recipients in Vietnam.

Autor: Xuan NT; Department of Internal Medicine, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam., Hop VQ; Department of Clinical Biochemistry, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam., Kien TQ; Department of Nephrology and Dialysis, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam., Toan PQ; Department of Nephrology and Dialysis, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam., Thang LV; Department of Nephrology and Dialysis, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam., Binh HT; Department of Nephrology and Dialysis, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam., Van Tran P; Department of Clinical Biochemistry, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam., Minh HT; Department of Clinical Biochemistry, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam., Man PT; Department of Pharmacy, National Hospital of Dermatology and Venereology, Hanoi, Vietnam., Cuong HX; Department of Occupational Medicine, Vietnam Military Medical University, Hanoi, Vietnam., Ben NH; Department of Occupational Medicine, Vietnam Military Medical University, Hanoi, Vietnam., Phuong NM; Department of Occupational Medicine, Vietnam Military Medical University, Hanoi, Vietnam., Linh NT; Department of Occupational Medicine, Vietnam Military Medical University, Hanoi, Vietnam., Linh NT; Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam; Faculty of Biology, National University of Hanoi, Hanoi, Vietnam., Dung VD; Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam; Hanoi University of Science and Technology, Hanoi, Vietnam., Quyen LTB; Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam., Hang DTT; Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam., Su HX; Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam. Electronic address: hoangxuansu@vmmu.edu.vn.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2022 Oct; Vol. 54 (8), pp. 2140-2146. Date of Electronic Publication: 2022 Sep 06.
DOI: 10.1016/j.transproceed.2022.07.009
Abstrakt: Background: This study aims to investigate the frequencies and association of CYP3A5 polymorphism with tacrolimus concentration among renal transplant recipients in Vietnam.
Methods: Sixty-eight kidney transplant recipients were included in this study from the department of nephrology and dialysis, Military Hospital 103. Blood samples were collected for monitoring of tacrolimus levels and determination of CYP3A5 genetic polymorphism.
Results: A total of 68 patients studied. The CYP3A5*3*3, CYP3A5*1*3, and CYP3A5*1*1 genotypes were detected in 48 (70.6%), 16 (23.5%), and 4 (5.9%), respectively. Tacrolimus concentrations were much lower in CYP3A5 expressors than in CYP3A5 nonexpressors on the first day, month 1, 3, 6, and 12 (5.98 ± 1.05 vs 6.57 ± 1.03, P = .03; 5.79 ± 1.13 vs 6.82 ± 1.05, P < .001; 4.76 ± 1.48 vs 6.73 ± 1.09, P < .001; 4.29 ± 1.64 vs 6.46 ± 1.23, P < .001; 4.20 ± 1.36 vs 6.04 ± 1.26, P < .001), respectively. Notably, the concentration/dose ratio in the CYP3A5 expressors was lower than in CYP3A5 nonexpressors at time points of follow up (P < .001). However, there were no significant differences in the age, sex, HLA mismatch, type of donors, acute rejection, and creatinine levels at time points between group of CYP3A5 expressors and those of CYP3A5 nonexpressors.
Conclusion: In conclusion, this research indicated the significant association of CYP3A5 genetic polymorphism with daily dose and tacrolimus concentrations in renal transplant recipients. This study provided a closer step to individualize the dose of tacrolimus in renal transplant patients in Vietnam.
Competing Interests: DISCLOSURES The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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