Restoration of vascular endothelial integrity by mesenchymal stromal/stem cells in debilitating virus diseases.

Autor: Balakrishna Pillai A; MGM Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, 607 402, India. agiesh.b@gmail.com., Mariappan V; MGM Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, 607 402, India., JeanPierre AR; MGM Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, 607 402, India., Rao SR; Research, Innovation and Development (R,I&D), Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, 607 402, India.
Jazyk: angličtina
Zdroj: Human cell [Hum Cell] 2022 Nov; Vol. 35 (6), pp. 1633-1639. Date of Electronic Publication: 2022 Sep 06.
DOI: 10.1007/s13577-022-00785-3
Abstrakt: Endothelial dysfunction is one of the key cornerstone complications of emerging and re-emerging viruses which lead to vascular leakage and a high mortality rate. The mechanism that regulates the origin of endothelial dysregulation is not completely elucidated. Currently, there are no potential pharmacological treatments and curable management for such diseases. In this sense, mesenchymal stromal/stem cells (MSCs) has been emerging to be a promising therapeutic strategy in restoring endothelial barrier function in various lung disease, including ALI and ARDS. The mechanism of the role of MSCs in restoring endothelial integrity among single-strand RNA (ssRNA) viruses that target endothelial cells remains elusive. Thus, we have discussed the therapeutic role of MSCs in restoring vascular integrity by (i) inhibiting the metalloprotease activity thereby preventing the cleavage of tight junction proteins, which are essential for maintaining membrane integrity (ii) possessing antioxidant properties which neutralize the excessive ROS production due to virus infection and its associated hyper host immune response (iii) modulating micro RNAs that regulate the endothelial activation and its integrity by downregulating the inflammatory response during ssRNA infection.
(© 2022. The Author(s) under exclusive licence to Japan Human Cell Society.)
Databáze: MEDLINE
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