Image analysis reveals differences in tumor multinucleations in Black and White patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma.

Autor: Koyuncu CF; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.; Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA., Nag R; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA., Lu C; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA., Corredor G; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.; Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA., Viswanathan VS; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA., Sandulache VC; Baylor College of Medicine, Houston, Texas, USA.; Otolaryngology-Head and Neck Surgery, Operative Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA., Fu P; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Yang K; Cleveland Clinic Foundation, Cleveland, Ohio, USA., Pan Q; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Zhang Z; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA., Xu J; Nanjing University of Information Science and Technology, Nanjing, China., Chute DJ; Cleveland Clinic Foundation, Cleveland, Ohio, USA., Thorstad WL; Washington University in St. Louis, St. Louis, Missouri, USA., Faraji F; University of California San Diego, San Diego, California, USA., Bishop JA; University of Texas Southwestern Medical Center, Dallas, Texas, USA., Mehrad M; Vanderbilt University Medical Center, Nashville, Tennessee, USA., Castro PD; Baylor College of Medicine, Houston, Texas, USA., Sikora AG; Baylor College of Medicine, Houston, Texas, USA., Thompson LDR; Southern California Permanente Medical Group, Pasadena, California, USA., Chernock RD; Washington University in St. Louis, St. Louis, Missouri, USA., Lang Kuhs KA; Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wasman JK; School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Luo JR; Washington University in St. Louis, St. Louis, Missouri, USA., Adelstein DJ; Cleveland Clinic Foundation, Cleveland, Ohio, USA., Koyfman SA; Cleveland Clinic Foundation, Cleveland, Ohio, USA., Lewis JS Jr; Vanderbilt University Medical Center, Nashville, Tennessee, USA., Madabhushi A; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.; Atlanta Veterans Administration Medical Center, Atlanta, Georgia, USA.; Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Jazyk: angličtina
Zdroj: Cancer [Cancer] 2022 Nov 01; Vol. 128 (21), pp. 3831-3842. Date of Electronic Publication: 2022 Sep 06.
DOI: 10.1002/cncr.34446
Abstrakt: Background: Understanding biological differences between different racial groups of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) patients, who have differences in terms of incidence, survival, and tumor morphology, can facilitate accurate prognostic biomarkers, which can help develop personalized treatment strategies.
Methods: This study evaluated whether there were morphologic differences between HPV-associated tumors from Black and White patients in terms of multinucleation index (MuNI), an image analysis-derived metric that measures density of multinucleated tumor cells within epithelial regions on hematoxylin-eosin images and previously has been prognostic in HPV-associated OPSCC patients. In this study, the authors specifically evaluated whether the same MuNI cutoff that was prognostic of overall survival (OS) and disease-free survival in their previous study, T TR , is valid for Black and White patients, separately. We also evaluated population-specific cutoffs, T B for Blacks and T W for Whites, for risk stratification.
Results: MuNI was statistically significantly different between Black (mean, 3.88e-4; median, 3.67e-04) and White patients (mean, 3.36e-04; median, 2.99e-04), with p = .0078. Using T TR , MuNI was prognostic of OS in the entire population with hazard ratio (HR) of 1.71 (p = .002; 95% confidence interval [CI], 1.21-2.43) and in White patients with HR of 1.72 (p = .005; 95% CI, 1.18-2.51). Population-specific cutoff, T W , yielded improved HR of 1.77 (p = .003; 95% CI, 1.21-2.58) for White patients, whereas T B did not improve risk-stratification in Black patients with HR of 0.6 (p = .3; HR, 0.6; 95% CI, 0.2-1.80).
Conclusions: Histological difference between White and Black patient tumors in terms of multinucleated tumor cells suggests the need for considering population-specific prognostic biomarkers for personalized risk stratification strategies for HPV-associated OPSCC patients.
(© 2022 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.)
Databáze: MEDLINE
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