Lactational exposure to venlafaxine provokes late repercussions on reproductive parameters in male rat offspring.

Autor: da Silva Moreira S; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo State, Brazil., de Matos Manoel B; School of Health Sciences, Federal University of Grande Dourados, UFGD, Dourados, Mato Grosso do Sul State, Brazil., Inácio JPG; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo State, Brazil., de Souza CG; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo State, Brazil., Reis ACC; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo State, Brazil., Jorge BC; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo State, Brazil., de Aquino AM; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo State, Brazil., Scarano WR; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo State, Brazil., Cardoso CAL; Mato Grosso do Sul State University, UEMS, Dourados, Mato Grosso do Sul State, Brazil., Arena AC; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, UNESP - Univ. Estadual Paulista, Botucatu, São Paulo State, Brazil.; Center of Toxicological Assistance (CEATOX), Institute of Biosciences of Botucatu, Univ. Estadual Paulista - Botucatu (UNESP), São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of applied toxicology : JAT [J Appl Toxicol] 2023 Mar; Vol. 43 (3), pp. 387-401. Date of Electronic Publication: 2022 Sep 10.
DOI: 10.1002/jat.4389
Abstrakt: Exposure to selective serotonin reuptake inhibitors can affect hormone-dependent processes, such as the brain sexual differentiation. Because the use of these antidepressants cause concern during lactation, we evaluated the possible effects of venlafaxine on lactational exposure and its late repercussions on reproductive parameters in male rats. Lactating rats were exposed to venlafaxine (3.85, 7.7, or 15.4 mg/kg/body weight; gavage), from lactational day 1 to 20. Venlafaxine and O-desmethylvenlafaxine residues were found in all milk samples of dams treated, demonstrating the lactational transfer of this antidepressant to the offspring. Although the maternal behavior was normal, the dams presented an increase in urea and uric acid levels in the groups treated with 7.7 and 15.4, respectively, as well as a spleen weight increased in the 3.85 and 15.4 groups. The male offspring showed a decrease in play behavior parameters in the intermediate dose group. Sperm analysis indicated a reduction in sperm motility in all treated groups. The androgen receptor expression in the hypothalamus was decreased in the highest dose group, although the sexual behavior had not been affected. In conclusion, venlafaxine was transferred through breast milk and promoted changes in play behavior, sperm quality, and hypothalamic androgen receptor (AR) content, which may indicate an incomplete masculinization of the brain of male offspring.
(© 2022 John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: