Prevalence of cancer as a comorbid in COVID-19 patients and their characteristics: a meta-analysis study.
| Autor: | Sitanggang JS; Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Siregar KB; Department of Surgery, Oncology Subdivision, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Sitanggang HH; Department of Surgery, Head and Neck Oncology Subdivision, Faculty of Medicine, Deli Serdang Hospital, Deli Serdang, Indonesia., Sprinse Vinolina N; Statistics Division, Universitas Sumatera Utara, Medan, Indonesia. |
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| Jazyk: | angličtina |
| Zdroj: | F1000Research [F1000Res] 2021 Sep 27; Vol. 10, pp. 975. Date of Electronic Publication: 2021 Sep 27 (Print Publication: 2021). |
| DOI: | 10.12688/f1000research.53539.2 |
| Abstrakt: | Background: Cancer patients are considered susceptible to coronavirus disease (COVID-19) due to an immunosuppressive state. This study determined the prevalence of cancer as a comorbid in COVID-19 patients, severe events, case fatality rate, history of anticancer therapy associated with severe events, and type of cancer in cancer patients with COVID-19 in the world. Methods: This study used a meta-analysis study approach, sourcing studies from various countries related to cancer and COVID-19. Inclusion and exclusion criteria were established to select studies. A PRISMA flowchart was presented to assess the selection process. Data from inclusion studies were analyzed using Review Manager 5.4. Results: The prevalence of cancer as a comorbid in COVID-19 patients was 4.63% (95% CI, 3.78-5.49%) worldwide. The lowest prevalence was the Asian study group with 2.36% (95% CI, 1.86-2.87%) and the highest prevalence was the European study group with 10.93% (95% CI, 6.62-15.24%). About 43.26% (95% CI, 34.71-51.80%) of COVID-19 patients with cancer as comorbid experienced severe events of COVID-19. In total, 58.13% (95% CI, 42.79-73.48%) of COVID-19 patients with cancer as a comorbid who in the last month had a history of anticancer therapy experienced severe events. The prevalence of lung cancer in cancer patients with COVID-19 was 20.23% (95% CI, 7.67-32.78%). Forest plots are also presented related to the results of meta-analysis research. Conclusions: High prevalence of cancer as a comorbid among COVID-19 patients indicates the susceptibility of cancer patients to SARS-CoV-2 infection. Cancer as a comorbid in COVID-19 patients and use of anticancer therapy increase severe events of COVID-19. Competing Interests: No competing interests were disclosed. (Copyright: © 2022 Sitanggang JS et al.) |
| Databáze: | MEDLINE |
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