Good maternal and fetal outcomes of three consecutive pregnancies in a Mediterranean woman with Alport syndrome: a case report.

Autor: Rawashdeh H; Obstetrics and Gynecology Department, Jordan University of Science and Technology, Irbid, Jordan. hmrawashdeh@just.edu.jo., Alchalabi HA; Obstetrics and Gynecology Department, Jordan University of Science and Technology (Retired), Irbid, Jordan., Oweis AO; Internal Medicine Department, Jordan University of Science and Technology, Irbid, Jordan., Al Jalodi H; Obstetrics and Gynecology Department at King Abdulla University Hospital. Higher specialization in medicine at Jordan University of Science and Technology, Irbid, Jordan.
Jazyk: angličtina
Zdroj: Journal of medical case reports [J Med Case Rep] 2022 Sep 01; Vol. 16 (1), pp. 328. Date of Electronic Publication: 2022 Sep 01.
DOI: 10.1186/s13256-022-03565-7
Abstrakt: Background: Alport syndrome is a rare inherited disorder affecting the glomerular basement membrane, manifested by hematuria and proteinuria that is commonly associated with ocular and hearing defects. There is limited information about the maternal and fetal outcomes of Alport syndrome in pregnancy.
Case Presentation: We describe a smooth course of pregnancy, a good maternal outcome, and a good fetal outcome in three consecutive pregnancies for a 35-year-old Mediterranean woman with Alport syndrome over a 10-year duration. Although there was a nephrotic range of progressive proteinuria in all her pregnancies, there was a prompt drop in proteinuria within 2 weeks of her deliveries. She has constantly shown a normal serum creatinine level and a normal serum protein level in all her pregnancies. Apart from a single episode of asymptomatic hypertension in her second pregnancy at 34 weeks of gestation that returned to a normal range immediately after delivery, she was normotensive antenatally and postnatally. She gave birth by cesarean section to three healthy newborns.
Conclusions: A normal prepregnancy creatinine level and a mild range of proteinuria in a patient with normotension, who is not on any medication, are associated with good maternal and fetal outcomes. Furthermore, successful pregnancy that is followed by a normal renal function test might suggest a favorable outcome for any future pregnancy.
(© 2022. The Author(s).)
Databáze: MEDLINE
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