Chronic clomipramine treatment reverses depressogenic-like effects of a chronic treatment with dexamethasone in rats.

Autor:	Laaziz A; Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco., El Mostafi H; Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco., Elhessni A; Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco., Touil T; Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.; Higher Institute of Nursing and Health Professions of Rabat, Morocco., Doumar H; Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco., Mesfioui A; Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Jazyk:	angličtina
Zdroj:	IBRO neuroscience reports [IBRO Neurosci Rep] 2022 Aug 01; Vol. 13, pp. 147-155. Date of Electronic Publication: 2022 Aug 01 (Print Publication: 2022).
DOI:	10.1016/j.ibneur.2022.07.007
Abstrakt:	Corticosteroids are widely used in medicine, for their anti-inflammatory and immunosuppressive actions, but can lead to troubling psychiatric side-effects. In fact, corticosteroids can induce many symptoms and syndromes, for example, mood disorders, anxiety and panic disorder, suicidal thinking and behavior. Furthermore, chronic stress and the administration of exogenous glucocorticoids are reported to induce affective changes in humans and rodents that relate to depressive state. Animal models are highly useful tools for studying the depression etiology. Face validity, construct validity, and predictive validity are the main criteria to evaluate animal depression models. The present study aimed to investigate the behavioral, cognitive, and biochemical effects of a chronic administration of DEX on Wistar rats. Wistar rats were administered daily with DEX (1.5 mg/kg, i.p., 21 days) or saline, the clomipramine treatment (2 mg/kg, i.p.) was realized just after the DEX injections for 21 days. DEX induced changes were evaluated by: forced swimming, novelty suppressed feeding, saccharin preference, open field, Morris water maze, and oxidative stress state in the brain. Results showed that chronic DEX administration conduct to a range of depression-related behavioral traits, including anhedonia, despair, weight loss, anxiety-like behavior, and cognitive impairments, which fill the face validity criterion. The DEX induced behavioral changes may result from the massive production of oxidative stress agents. This sustains the etiological hypothesis claiming that hyper-circulating glucocorticoid resulting from HPA dysfunction induces damage in certain neural structures related to depressive disorder, essentially the hippocampus. The antidepressant treatment has restored the behavioral state of rats which fills the predictive validity criterion. Competing Interests: None. (© 2022 The Authors.)
Databáze:	MEDLINE
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