Maternal safflower oil consumption improve reflex maturation, memory and reduces hippocampal oxidative stress in the offspring rats treated during pregnancy and lactation.

Autor: de Souza MA; Food Science and Tecnology Program, Federal University of Paraíba, João Pessoa, Brazil. Electronic address: mikaelleas@gmail.com., Gomes MSC; Department of Nutrition, Federal University of Campina Grande, Cuité, Brazil., da Silva AE; Department of Nutrition, Federal University of Campina Grande, Cuité, Brazil., da Costa Rangel R; Department of Nutrition, Federal University of Campina Grande, Cuité, Brazil., Braz GRF; Laboratory of Biochemistry and Exercise Biochemistry, Department of Physical Education and Sports Science, CAV-Federal University of Pernambuco, Recife, Brazil., Pedroza AA; Laboratory of Biochemistry and Exercise Biochemistry, Department of Physical Education and Sports Science, CAV-Federal University of Pernambuco, Recife, Brazil., Costa LAR; Department of Nutrition, Federal University of Pernambuco, Recife, Brazil., Batista-de-Oliveira-Hornsby M; Department of Nutrition, Federal University of Pernambuco, Recife, Brazil., Lagranha CJ; Department of Nutrition, Federal University of Pernambuco, Recife, Brazil., de Menezes Santos Bertozzo CC; Department of Nutrition, Federal University of Campina Grande, Cuité, Brazil., de Melo MFFT; Department of Nutrition, Federal University of Campina Grande, Cuité, Brazil., Soares JKB; Department of Nutrition, Federal University of Campina Grande, Cuité, Brazil.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2022 Dec 01; Vol. 318, pp. 33-39. Date of Electronic Publication: 2022 Aug 25.
DOI: 10.1016/j.jad.2022.08.058
Abstrakt: Objective: Evaluate the influence of maternal consumption of safflower oil on reflex maturation, memory and offspring hippocampal oxidative stress.
Methodology: Two groups were formed: control group (C), whose mothers received a standard diet, and Safflower group (SF), whose mothers received a normolipidic diet with safflower oil as lipid source. Treatment was given from the 14th day of gestation and throughout lactation. To evaluate newborn development, the reflex ontogeny indicators between the 1st and the 21st days of life were evaluated; to assess memory, from the 42nd day of life on these animals were examined on open field habituation and novel object recognition test. Following behavioral analysis, the animals were anesthetized and decapitated. Hippocampus was rapidly dissected. In the hippocampal tissues, we evaluated the levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione S transferase (GST) and reduced glutathione (GSH).
Results: SF offspring showed delayed maturation of reflexes and improvement of novel object recognition in short-term and long-term (p < 0.05). Safflower oil decreases lipid peroxidation evaluated by MDA levels (p < 0.001) and increases antioxidant defenses as shown by SOD, CAT, GST and GSH levels (p < 0.05). In our study, the composition of flavonoids present in the oil was not evaluated. Furthermore, in a future study, the effect of maternal consumption on female offspring should be verified.
Conclusion: Maternal intake of safflower oil could: (1) change neonate reflex parameters, (2) promote improvement of cognitive development in adolescence (3) improve antioxidant enzymatic and non-enzymatic defenses in the hippocampus.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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