Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy.

Autor:	Vásquez-Procopio J; Department of Immunobiochemistry, Instituto Nacional de Perinatología, Mexico City, Mexico.; Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico., Espejel-Nuñez A; Department of Immunobiochemistry, Instituto Nacional de Perinatología, Mexico City, Mexico., Torres-Torres J; Clinical Research Division, Instituto Nacional de Perinatología, Mexico City, Mexico., Martinez-Portilla RJ; Clinical Research Division, Instituto Nacional de Perinatología, Mexico City, Mexico., Espino Y Sosa S; Clinical Research Division, Instituto Nacional de Perinatología, Mexico City, Mexico., Mateu-Rogell P; Clinical Research Division, Instituto Nacional de Perinatología, Mexico City, Mexico., Ortega-Castillo V; Department of Obstetrics, Instituto Nacional de Perinatología, Mexico City, Mexico., Tolentino-Dolores M; Department of Nutrition and Bioprogramming, Instituto Nacional de Perinatología, Mexico City, Mexico., Perichart-Perera O; Department of Nutrition and Bioprogramming, Instituto Nacional de Perinatología, Mexico City, Mexico., Franco-Gallardo JO; Data Science Department, Openlab, Mexico City, Mexico., Carranco-Martínez JA; Department of Translational Medicine, Instituto Nacional de Perinatología, Mexico City, Mexico., Prieto-Rodríguez S; Department of Translational Medicine, Instituto Nacional de Perinatología, Mexico City, Mexico., Guzmán-Huerta M; Department of Translational Medicine, Instituto Nacional de Perinatología, Mexico City, Mexico., Missirlis F; Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico., Estrada-Gutierrez G; Research Division, Instituto Nacional de Perinatología, Mexico City, Mexico.
Jazyk:	angličtina
Zdroj:	Frontiers in cell and developmental biology [Front Cell Dev Biol] 2022 Aug 09; Vol. 10, pp. 935363. Date of Electronic Publication: 2022 Aug 09 (Print Publication: 2022).
DOI:	10.3389/fcell.2022.935363
Abstrakt:	Pregnancy makes women more susceptible to infectious agents; however, available data on the effect of SARS-CoV-2 on pregnant women are limited. To date, inflammatory responses and changes in serum metal concentration have been reported in COVID-19 patients, but few associations between metal ions and cytokines have been described. The aim of this study was to evaluate correlations between inflammatory markers and serum metal ions in third-trimester pregnant women with varying COVID-19 disease severity. Patients with severe symptoms had increased concentrations of serum magnesium, copper, and calcium ions and decreased concentrations of iron, zinc, and sodium ions. Potassium ions were unaffected. Pro-inflammatory cytokines IL-6, TNF-α, IL-8, IL-1α, anti-inflammatory cytokine IL-4, and the IP-10 chemokine were induced in the severe presentation of COVID-19 during pregnancy. Robust negative correlations between iron/magnesium and zinc/IL-6, and a positive correlation between copper/IP-10 were observed in pregnant women with the severe form of the disease. Thus, coordinated alterations of serum metal ions and inflammatory markers - suggestive of underlying pathophysiological interactions-occur during SARS-CoV-2 infection in pregnancy. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Vásquez-Procopio, Espejel-Nuñez, Torres-Torres, Martinez-Portilla, Espino Y. Sosa, Mateu-Rogell, Ortega-Castillo, Tolentino-Dolores, Perichart-Perera, Franco-Gallardo, Carranco-Martínez, Prieto-Rodríguez, Guzmán-Huerta, Missirlis and Estrada-Gutierrez.)
Databáze:	MEDLINE
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