Promising Antimycobacterial Activities of Flavonoids against Mycobacterium sp. Drug Targets: A Comprehensive Review.

Autor: Rabaan AA; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.; College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.; Department of Public Health and Nutrition, The University of Haripur, Haripur 22610, Pakistan., Alhumaid S; Administration of Pharmaceutical Care, Al-Ahsa Health Cluster, Ministry of Health, Al-Ahsa 31982, Saudi Arabia., Albayat H; Infectious Disease Department, King Saud Medical City, Riyadh 7790, Saudi Arabia., Alsaeed M; Infectious Disease Division, Department of Medicine, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia., Alofi FS; Department of Infectious Diseases, King Fahad Hospital, Madinah 42351, Saudi Arabia., Al-Howaidi MH; Clinical Microbiology Division, Medical Laboratory Department, Qatif Health Network, Qatif 31911, Saudi Arabia., Turkistani SA; Fakeeh College for Medical Science, Jeddah 21134, Saudi Arabia., Alhajri SM; Infectious and Zoonotic Diseases Division, Ministry of Environment, Water and Agriculture, Al-Ahsa 11116, Saudi Arabia., Alahmed HE; Department of Laboratory and Blood Bank, King Fahad Hospital, Al Hofuf 36441, Saudi Arabia., Alzahrani AB; Molecular Diagnostic Laboratory, King Fahad Armed Forces Hospital, Jeddah 21159, Saudi Arabia., Mashraqi MM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran 61441, Saudi Arabia., Alwarthan S; Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia., Alhajri M; Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia., Alshahrani FS; Department of Internal Medicine, College of Medicine, King Saud University, Riyadh 11362, Saudi Arabia.; Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, King Saud University and King Saud University Medical City, Riyadh 11451, Saudi Arabia., Almuthree SA; Department of Infectious Disease, King Abdullah Medical City, Makkah 43442, Saudi Arabia., Alsubki RA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11362, Saudi Arabia., Abuzaid AA; Medical Microbiology Department, Security Forces Hospital Programme, Dammam 32314, Saudi Arabia., Alfaresi M; Department of Pathology and Laboratory Medicine, Sheikh Khalifa General Hospital, Umm Al Quwain P.O. Box 499, United Arab Emirates.; Department of Pathology, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates., Al Fares MA; Department of Internal Medicine, King Abdulaziz University Hospital, Jeddah 21589, Saudi Arabia., Mutair AA; Research Center, Almoosa Specialist Hospital, Al-Ahsa 36342, Saudi Arabia.; College of Nursing, Princess Norah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia.; School of Nursing, Wollongong University, Wollongong, NSW 2522, Australia.; Nursing Department, Prince Sultan Military College of Health Sciences, Dhahran 33048, Saudi Arabia.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2022 Aug 22; Vol. 27 (16). Date of Electronic Publication: 2022 Aug 22.
DOI: 10.3390/molecules27165335
Abstrakt: Tuberculosis (TB) caused by the bacterial pathogen Mycobacterium tuberculosis ( Mtb ) remains a threat to mankind, with over a billion of deaths in the last two centuries. Recent advancements in science have contributed to an understanding of Mtb pathogenesis and developed effective control tools, including effective drugs to control the global pandemic. However, the emergence of drug resistant Mtb strains has seriously affected the TB eradication program around the world. There is, therefore, an urgent need to develop new drugs for TB treatment, which has grown researchers' interest in small molecule-based drug designing and development. The small molecules-based treatments hold significant potential to overcome drug resistance and even provide opportunities for multimodal therapy. In this context, various natural and synthetic flavonoids were reported for the effective treatment of TB. In this review, we have summarized the recent advancement in the understanding of Mtb pathogenesis and the importance of both natural and synthetic flavonoids against Mtb infection studied using in vitro and in silico methods. We have also included flavonoids that are able to inhibit the growth of non-tubercular mycobacterial organisms. Hence, understanding the therapeutic properties of flavonoids can be useful for the future treatment of TB.
Databáze: MEDLINE
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