Genetic assortative mating for schizophrenia and bipolar disorder.

Autor:	Jefsen OH; Psychosis Research Unit, Aarhus University Hospital, Central Denmark Region, Aarhus, Denmark., Nudel R; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; CORE - Copenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Wang Y; Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway., Bybjerg-Grauholm J; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institute, Copenhagen, Denmark., Hemager N; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; CORE - Copenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; Child and Adolescent Mental Health Centre - Research Unit, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark., Christiani CAJ; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; CORE - Copenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Burton BK; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Child and Adolescent Mental Health Centre - Research Unit, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Spang KS; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Child and Adolescent Mental Health Centre - Research Unit, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark., Ellersgaard D; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; CORE - Copenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Gantriis DL; Psychosis Research Unit, Aarhus University Hospital, Central Denmark Region, Aarhus, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark., Plessen KJ; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Child and Adolescent Mental Health Centre - Research Unit, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.; Division of Child and Adolescent Psychiatry, Department of Psychiatry, University Hospital Lausanne and University of Lausanne, Lausanne, Switzerland., Jepsen JRM; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; CORE - Copenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; Child and Adolescent Mental Health Centre - Research Unit, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.; Mental Health Services in the Capital Region of Denmark, Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Hellerup, Denmark., Thorup AAE; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Child and Adolescent Mental Health Centre - Research Unit, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Werge T; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark., Nordentoft M; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; CORE - Copenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mors O; Psychosis Research Unit, Aarhus University Hospital, Central Denmark Region, Aarhus, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark., Greve AN; Psychosis Research Unit, Aarhus University Hospital, Central Denmark Region, Aarhus, Denmark.; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Jazyk:	angličtina
Zdroj:	European psychiatry : the journal of the Association of European Psychiatrists [Eur Psychiatry] 2022 Aug 23; Vol. 65 (1), pp. e53. Date of Electronic Publication: 2022 Aug 23.
DOI:	10.1192/j.eurpsy.2022.2304
Abstrakt:	Background: Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRSs). Methods: PRSs from The Danish High-Risk and Resilience Study-VIA 7 were compared between parents in three subsamples: population-based control parent pairs ( N =198), parent pairs where at least one parent had schizophrenia ( N =193), and parent pairs where at least one parent had bipolar disorder ( N =115). Results: The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed a significant correlation between parent pairs ( r =0.121, p =0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs ( r =0.162, p =0.0067), but it was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions: Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia.
Databáze:	MEDLINE
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