Evaluation of facial hair-associated SNPs: a pilot study on male Pakistani Punjabi population.

Autor: Jawad M; Department of Forensic Sciences, University of Health Sciences, Lahore, Pakistan., Adnan A; Department of Anthropology and Ethnology, Institute of Anthropology, School of Sociology and Anthropology, Xiamen University, Xiamen, China. mirzaatifadnan@gmail.com.; Department of Forensic Sciences, College of Criminal Justice, Naif Arab University of Security Sciences, Riyadh, 11452, Kingdom of Saudi Arabia. mirzaatifadnan@gmail.com., Rehman RA; Department of Forensic Sciences, University of Health Sciences, Lahore, Pakistan., Nazir S; Department of Forensic Sciences, University of Health Sciences, Lahore, Pakistan., Adeyemo OA; Department of Cell Biology and Genetics, Faculty of Science, University of Lagos, AkokaLagos, Yaba, Nigeria., Amer SAM; Department of Forensic Sciences, College of Criminal Justice, Naif Arab University of Security Sciences, Riyadh, 11452, Kingdom of Saudi Arabia., Hadi S; Department of Forensic Sciences, College of Criminal Justice, Naif Arab University of Security Sciences, Riyadh, 11452, Kingdom of Saudi Arabia., Liu F; Department of Forensic Sciences, College of Criminal Justice, Naif Arab University of Security Sciences, Riyadh, 11452, Kingdom of Saudi Arabia.; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China., Wang CC; Department of Anthropology and Ethnology, Institute of Anthropology, School of Sociology and Anthropology, Xiamen University, Xiamen, China. wang@xmu.edu.cn., Rakha A; Department of Forensic Sciences, University of Health Sciences, Lahore, Pakistan. dnaexpert@me.com.
Jazyk: angličtina
Zdroj: Forensic science, medicine, and pathology [Forensic Sci Med Pathol] 2023 Sep; Vol. 19 (3), pp. 293-302. Date of Electronic Publication: 2022 Aug 22.
DOI: 10.1007/s12024-022-00515-z
Abstrakt: Variation in facial hair is one of the most conspicuous features of facial appearance, particularly in South Asia and Middle East countries. A genome-wide association study in Latin Americans has identified multiple genetic variants at distinct loci being associated with facial hair traits including eyebrow thickness, beard thickness, and monobrow. In this pilot study, we have evaluated 16 SNPs associated with facial hair traits in 58 male individuals from the Punjabi population of Pakistan. In our sample, rs365060 in EDAR and rs12597422 in FTO showed significant association with monobrow, rs6684877 in MACF1 showed significant association with eyebrow thickness, and two SNPs in LOC105379031 (rs9654415 and rs7702331) showed significant association with beard thickness. Our results also suggest that genetic association may vary between ethnic groups and geographic regions. Although more data are needed to validate our results, our findings are of value in forensic molecular photofitting research in Pakistan.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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