Clinical manifestations and healthcare utilization before diagnosis of transthyretin amyloidosis.
| Autor: | Nativi-Nicolau J; Mayo Clinic, Jacksonville, FL 32224, USA., Fine NM; University of Calgary, Calgary, AB, T2N 1N4, Canada., Ortiz-Pérez JT; Amyloidosis & Myeloma Unit, Hospital Clínic Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Villarroel 170, Barcelona, 08036, Spain., Brown D; Ionis Pharmaceuticals, Inc., One Beacon Street, Boston, MA 02108, USA., Vera-Llonch M; Ionis Pharmaceuticals, Inc., One Beacon Street, Boston, MA 02108, USA., Reddy SR; PHAR (Partnership for Health Analytic Research), Beverly Hills, CA 90212, USA., Chang E; PHAR (Partnership for Health Analytic Research), Beverly Hills, CA 90212, USA., Tarbox MH; PHAR (Partnership for Health Analytic Research), Beverly Hills, CA 90212, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of comparative effectiveness research [J Comp Eff Res] 2022 Oct; Vol. 11 (14), pp. 1031-1044. Date of Electronic Publication: 2022 Aug 22. |
| DOI: | 10.2217/cer-2022-0074 |
| Abstrakt: | Introduction: Initial clinical manifestations of transthyretin amyloidosis (ATTR) are not well understood, making timely diagnosis challenging. Methods: Patients aged ≥68 years newly diagnosed with ATTR were identified using Medicare Research Identifiable Files. Symptom manifestation and healthcare utilization were measured during 3 years pre-diagnosis; demographics and comorbidity index during 1-year pre-diagnosis. Controls (ATTR-free) were matched 1:1 to patients with ATTR based on age, sex and region; same index date and enrollment as match. Results: We identified 552 matched ATTR-control pairs: mean age 78.3 (standard deviation 6.3) and 64.5% male. Among patients with ATTR (vs controls), cardiovascular conditions (92.9 vs 75.9%) and hospitalization (54.0 vs 35.5%) were frequent during 3 years pre-diagnosis. Conclusion: Patients with ATTR have multiple symptoms and hospitalizations pre-diagnosis, recognition of which may facilitate earlier diagnosis and treatment. |
| Databáze: | MEDLINE |
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