Evaluation of anthoxanthins and their actions on digestive enzyme inhibition when used independently and in combination.
| Autor: | Koh YQ; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore., Sin YAD; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore., Rong HJ; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore., Chua THS; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore., Ho SS; Hoow Foods Pte Ltd, 67 Ayer Rajah Crescent, Singapore., Ho HK; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore. |
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| Jazyk: | angličtina |
| Zdroj: | Heliyon [Heliyon] 2022 Aug 08; Vol. 8 (8), pp. e10131. Date of Electronic Publication: 2022 Aug 08 (Print Publication: 2022). |
| DOI: | 10.1016/j.heliyon.2022.e10131 |
| Abstrakt: | Carbohydrate digestibility is a key determinant for elevated postprandial hyperglycemia (PPHG). Apart from dietary restrictions, one of the strategies to reduce PPHG is to limit the activity of carbohydrate digestive enzymes within the gastrointestinal tract in order to reduce monosaccharide absorption rates. The present work aimed to assess the inhibitory capabilities of digestive enzymes (e.g., α-glucosidase and α-amylase) by anthoxanthins when used independently, in combination with acarbose, or with a different anthoxanthin. Our results showed that quercetin, myricetin, and luteolin presented lower IC Competing Interests: The authors declare no conflict of interest. (© 2022 The Author(s).) |
| Databáze: | MEDLINE |
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