Endothelial dysfunction: The possible link between cardiovascular comorbidities and phenomenon of inflammaging from COPD.

Autor:	Tudorache E; Center for Research and Innovation in Personalized Medicine of Respiratory Diseases, XIII Department - Pulmonology Discipline, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Timișoara, Romania.; I and II Clinic of Pulmonary Diseases, Clinical Hospital of Infectious Diseases and Pneumophthisiology 'Dr. Victor Babes' Timisoara, Timisoara, Romania., Fira-Mladinescu O; Center for Research and Innovation in Personalized Medicine of Respiratory Diseases, XIII Department - Pulmonology Discipline, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Timișoara, Romania.; I and II Clinic of Pulmonary Diseases, Clinical Hospital of Infectious Diseases and Pneumophthisiology 'Dr. Victor Babes' Timisoara, Timisoara, Romania., Traila D; Center for Research and Innovation in Personalized Medicine of Respiratory Diseases, XIII Department - Pulmonology Discipline, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Timișoara, Romania.; I and II Clinic of Pulmonary Diseases, Clinical Hospital of Infectious Diseases and Pneumophthisiology 'Dr. Victor Babes' Timisoara, Timisoara, Romania., Marc M; Center for Research and Innovation in Personalized Medicine of Respiratory Diseases, XIII Department - Pulmonology Discipline, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Timișoara, Romania.; I and II Clinic of Pulmonary Diseases, Clinical Hospital of Infectious Diseases and Pneumophthisiology 'Dr. Victor Babes' Timisoara, Timisoara, Romania., Rajnoveanu RM; Palliative Care Department, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania., Tofolean DE; III Department of Internal Medicine, Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania., Fildan AP; Center for Research and Innovation in Personalized Medicine of Respiratory Diseases, XIII Department - Pulmonology Discipline, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Timișoara, Romania.
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2022 Aug 19; Vol. 101 (33), pp. e30078.
DOI:	10.1097/MD.0000000000030078
Abstrakt:	Aging is a risk factor for many chronic noncommunicable diseases, including chronic obstructive pulmonary disease (COPD), which is often associated with cardiovascular disease (CVD). Moreover, aging is associated with a mild form of systemic inflammation. The aim of our study was to analyze the relationship between age, systemic and vascular inflammation, and the presence of CVD comorbidities in a stable COPD population. Forty COPD patients were divided into 2 age groups (<65 and ≥65 years of age), from which we collected the following inflammatory biomarkers: C-reactive protein, tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and endothelin-1 (ET-1). Elderly COPD patients had more frequent exacerbation events per year (2 vs 1, P = .06), a higher prevalence of CVD (3 vs 2, P = .04), more limited exercise tolerance (6-minute walking test distance, 343 [283-403] vs 434 [384-484]; P = .02), and mild systemic inflammation (TNF-α, 9.02 [7.08-10.96] vs 6.48 [5.21-7.76]; P = .03; ET-1, 2.24 [1.76-2.71] vs 1.67 [1.36-1.98] pg/mL; P = .04). A weak correlation between age and ET-1 (r = 0.32, P = .04) was observed. Mild systemic inflammation, characterized by a slightly increased level of TNF-α, and endothelial dysfunction, marked by elevated ET-1, could be liaisons between aging, COPD, and CVD comorbidities. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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