Quantitative assessment of emphysema and bronchial wall thickness in patients with stable chronic obstructive pulmonary disease: comparison between the eosinophilic and non-eosinophilic phenotypes.

Autor:	Stival RSM; Complexo Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Rabelo LM; Complexo Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Leão GL; Complexo Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Drevenowski D; Complexo Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Serafini J; Complexo Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Vieira VLG; Complexo Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil., Escuissato DL; Complexo Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil.
Jazyk:	angličtina
Zdroj:	Radiologia brasileira [Radiol Bras] 2022 Jul-Aug; Vol. 55 (4), pp. 209-215.
DOI:	10.1590/0100-3984.2021.0088
Abstrakt:	Objective: To perform a quantitative assessment of bronchial wall thickening and the emphysema score in patients with stable chronic obstructive pulmonary disease (COPD), comparing the eosinophilic and non-eosinophilic COPD phenotypes. Materials and Methods: This was a retrospective observational study of patients with COPD followed between August 2018 and July 2019. The patients were divided into two groups by the eosinophil count in peripheral blood: eosinophilic (≥ 300 cells/µL); and non-eosinophilic (< 300 cells/µL). Quantitative, automated assessments of emphysema and bronchial wall thickness were performed by evaluating computed tomography scans of the chest. Results: We evaluated the records of 110 patients diagnosed with COPD: 28 (25.5%) in the eosinophilic group; and 82 (74.5%) in the non-eosinophilic group. The demographic, clinical, functional, and therapeutic variables were comparable between the two groups. There were no significant differences between the two groups in terms of the emphysema score or bronchial wall thickness ( p > 0.05 for both). Conclusion: Patients with eosinophilic COPD do not appear to have lower emphysema scores or greater bronchial wall thickening than do those with non-eosinophilic phenotypes of the disease.
Databáze:	MEDLINE
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