Anaplastic ganglioglioma-A diagnosis comprising several distinct tumour types.

Autor: Reinhardt A; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Pfister K; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Pathology, Kantonsspital Winterthur, Winterthur, Switzerland., Schrimpf D; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Stichel D; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Sahm F; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Reuss DE; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Capper D; Department of Neuropathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany., Wefers AK; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ebrahimi A; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neuropathology, University of Bonn, Bonn, Germany., Sill M; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany., Felsberg J; Institute of Neuropathology, Heinrich Heine University, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany., Reifenberger G; Institute of Neuropathology, Heinrich Heine University, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany.; German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, German Cancer Research Center (DKFZ), Heidelberg, Germany., Becker A; Department of Neuropathology, University of Bonn, Bonn, Germany., Prinz M; Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.; Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Staszewski O; Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany., Hartmann C; Department of Neuropathology, Hannover Medical School, Hanover, Germany., Schittenhelm J; Institute of Pathology and Neuropathology, Comprehensive Cancer Center Tübingen, University Tübingen, Tübingen, Germany., Gramatzki D; Department of Neurology, University Hospital and University Zürich, Zürich, Switzerland., Weller M; Department of Neurology, University Hospital and University Zürich, Zürich, Switzerland., Olar A; NOMIX Laboratories, Denver, Colorado, USA., Rushing EJ; Institute of Neuropathology, University Hospital Zürich (USZ), Zürich, Switzerland., Bergmann M; Institute of Neuropathology, Center for Pathology, Klinikum Bremen Mitte, Bremen, Germany., Farrell MA; Department of Neuropathology, Beaumont Hospital, Dublin, Ireland., Blümcke I; Department of Neuropathology, University Hospital Erlangen, Member of EpiCARE ERN, Erlangen, Germany., Coras R; Department of Neuropathology, University Hospital Erlangen, Member of EpiCARE ERN, Erlangen, Germany., Beckervordersandforth J; Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands., Kim SH; Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea., Rogerio F; Department of Pathology, University of Campinas (UNICAMP), Campinas, Brazil., Dimova PS; Epilepsy Surgery Center, Department of Neurosurgery, St. Ivan Rilski University Hospital, Sofia, Bulgaria., Niehusmann P; Section of Neuropathology, Department of Pathology, Oslo University Hospital, Oslo, Norway., Unterberg A; Clinic for Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany., Platten M; Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Clinical Cooperation Unit Neuroimmunology and Brain Tumour Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Pfister SM; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Paediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Paediatric Oncology and Hematology, University Hospital Heidelberg, Heidelberg, Germany., Wick W; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.; Neurology Clinic, University Hospital Heidelberg, Heidelberg, Germany., Herold-Mende C; Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany., von Deimling A; Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.
Jazyk: angličtina
Zdroj: Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2022 Dec; Vol. 48 (7), pp. e12847. Date of Electronic Publication: 2022 Sep 16.
DOI: 10.1111/nan.12847
Abstrakt: Aims: Anaplastic ganglioglioma is a rare tumour, and diagnosis has been based on histological criteria. The 5th edition of the World Health Organization Classification of Tumours of the Central Nervous System (CNS WHO) does not list anaplastic ganglioglioma as a distinct diagnosis due to lack of molecular data in previous publications. We retrospectively compiled a cohort of 54 histologically diagnosed anaplastic gangliogliomas to explore whether the molecular profiles of these tumours represent a separate type or resolve into other entities.
Methods: Samples were subjected to histological review, desoxyribonucleic acid (DNA) methylation profiling and next-generation sequencing. Morphological and molecular data were summarised to an integrated diagnosis.
Results: The majority of tumours designated as anaplastic gangliogliomas resolved into other CNS WHO diagnoses, most commonly pleomorphic xanthoastrocytoma (16/54), glioblastoma, isocitrate dehydrogenase protein (IDH) wild type and diffuse paediatric-type high-grade glioma, H3 wild type and IDH wild type (11 and 2/54), followed by low-grade glial or glioneuronal tumours including pilocytic astrocytoma, dysembryoplastic neuroepithelial tumour and diffuse leptomeningeal glioneuronal tumour (5/54), IDH mutant astrocytoma (4/54) and others (6/54). A subset of tumours (10/54) was not assignable to a CNS WHO diagnosis, and common molecular profiles pointing to a separate entity were not evident.
Conclusions: In summary, we show that tumours histologically diagnosed as anaplastic ganglioglioma comprise a wide spectrum of CNS WHO tumour types with different prognostic and therapeutic implications. We therefore suggest assigning this designation with caution and recommend comprehensive molecular workup.
(© 2022 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.)
Databáze: MEDLINE
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