A central alarm system that gates multi-sensory innate threat cues to the amygdala.

Autor:	Kang SJ; Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Liu S; Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Ye M; Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Kim DI; Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Pao GM; Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Okinawa 904-0495, Japan., Copits BA; Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Roberts BZ; Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA., Lee KF; Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Bruchas MR; Center of Excellence in the Neurobiology of Addiction, Pain, and Emotion, Departments of Anesthesiology and Pain Medicine, and Pharmacology, University of Washington, Seattle, WA 98195, USA., Han S; Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Department of Neurobiology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: sunghan@salk.edu.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2022 Aug 16; Vol. 40 (7), pp. 111222.
DOI:	10.1016/j.celrep.2022.111222
Abstrakt:	Perception of threats is essential for survival. Previous findings suggest that parallel pathways independently relay innate threat signals from different sensory modalities to multiple brain areas, such as the midbrain and hypothalamus, for immediate avoidance. Yet little is known about whether and how multi-sensory innate threat cues are integrated and conveyed from each sensory modality to the amygdala, a critical brain area for threat perception and learning. Here, we report that neurons expressing calcitonin gene-related peptide (CGRP) in the parvocellular subparafascicular nucleus in the thalamus and external lateral parabrachial nucleus in the brainstem respond to multi-sensory threat cues from various sensory modalities and relay negative valence to the lateral and central amygdala, respectively. Both CGRP populations and their amygdala projections are required for multi-sensory threat perception and aversive memory formation. The identification of unified innate threat pathways may provide insights into developing therapeutic candidates for innate fear-related disorders. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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