Common and differential neural mechanisms underlying mood disorders.

Autor: Rai S; Brain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Westmead, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, Westmead Clinical School, The University of Sydney, Sydney, New South Wales, Australia., Griffiths KR; Brain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Westmead, Sydney, New South Wales, Australia., Breukelaar IA; Brain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Westmead, Sydney, New South Wales, Australia.; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia., Barreiros AR; Brain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Westmead, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, Westmead Clinical School, The University of Sydney, Sydney, New South Wales, Australia., Boyce P; Specialty of Psychiatry, The University of Sydney School of Medicine, Sydney, New South Wales, Australia., Hazell P; Specialty of Psychiatry, The University of Sydney School of Medicine, Sydney, New South Wales, Australia., Foster SL; Department of Radiology, Westmead Hospital, New South Wales, Australia.; Faculty of Medicine and Health, Sydney School of Health Sciences, The University of Sydney, Sydney, New South Wales, Australia., Malhi GS; Specialty of Psychiatry, The University of Sydney School of Medicine, Sydney, New South Wales, Australia.; Department of Psychiatry, CADE Clinic, Royal North Shore Hospital, Sydney, New South Wales, Australia.; Department of Psychiatry, University of Oxford, Oxford, UK., Harris AWF; Brain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Westmead, Sydney, New South Wales, Australia.; Specialty of Psychiatry, The University of Sydney School of Medicine, Sydney, New South Wales, Australia., Korgaonkar MS; Brain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Westmead, Sydney, New South Wales, Australia.; Specialty of Psychiatry, The University of Sydney School of Medicine, Sydney, New South Wales, Australia.; Faculty of Medicine and Health, Sydney School of Health Sciences, The University of Sydney, Sydney, New South Wales, Australia.
Jazyk: angličtina
Zdroj: Bipolar disorders [Bipolar Disord] 2022 Dec; Vol. 24 (8), pp. 795-805. Date of Electronic Publication: 2022 Aug 25.
DOI: 10.1111/bdi.13248
Abstrakt: Background: Despite homogenous clinical presentations between bipolar and unipolar disorders, there are distinct neurobiological differences. Chronicity of illness may be a factor impacting and sustaining certain neural features. The goal of this study was to investigate common and shared neural mechanisms underlying mood disorders, and possible sustained neural changes relating to illness chronicity by investigating a cohort of euthymic patients with bipolar disorder (BD), unipolar depression who had responded to treatment (treatment-sensitive depression, TSD), and a chronically treatment-resistant depressed (TRD) group.
Methods: One hundred and seventy-two participants (40 BD, 39 TSD, 40 TRD, and 53 age-gender-matched healthy controls) underwent resting-state fMRI scans. Seed-based and independent component analyses were performed to investigate group differences in resting-state connectivity between the four groups.
Results: All three clinical groups had significantly lower connectivity within the frontoparietal network (FPN) relative to controls. TRD and BD were significantly different from TSD (TRD, BD > TSD) but were not significantly different from each other. TRDs were also significantly different from both BD and TSD for salience network connectivity with the posterior cingulate (DMN) and the FPN with frontal pole (DMN). Additionally, the BD group exhibited greater DMN-FPN (sgACC-RDLPFC) connectivity relative to TRD, TSD, and controls, which was correlated with a previous number of depressive episodes, in the BD group only.
Conclusions: BD demonstrated shared and differential connectivity features relative to symptomatic TRD and euthymic TSD groups. The increased sgACC-RDLPFC connectivity in BD and its correlation with a number of depressive episodes could be a neural feature associated with illness chronicity.
(© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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