Novel chlorine-extending polymer coating with prolonged antiviral activity against SARS-CoV-2.

Autor: Zhang Y; Halomine, Inc., Ithaca, NY, USA., Choi YW; Battelle Biomedical Research Center, West Jefferson, OH, USA., Demir B; Halomine, Inc., Ithaca, NY, USA., Ekbataniamiri F; Halomine, Inc., Ithaca, NY, USA., Fulton ML; Battelle Biomedical Research Center, West Jefferson, OH, USA., Ma M; Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA., Schang LM; Department of Microbiology and Immunology, Baker Institute for Animal Health, Cornell University, Ithaca, NY, USA., Purevdorj-Gage L; Halomine, Inc., Ithaca, NY, USA., Qiao M; Halomine, Inc., Ithaca, NY, USA.
Jazyk: angličtina
Zdroj: Letters in applied microbiology [Lett Appl Microbiol] 2022 Nov; Vol. 75 (5), pp. 1346-1353. Date of Electronic Publication: 2022 Aug 31.
DOI: 10.1111/lam.13804
Abstrakt: We previously reported a novel polymeric surface coating, namely, HaloFilm™ that can immobilize and extend the antimicrobial activity of chlorine on surfaces. In this study, we demonstrated the continuous antiviral efficacy of HaloFilm when applied on stainless steel and cotton gauze as two representative models for non-porous and porous surfaces against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Forty-eight hours post HaloFilm application and chlorination and 2 h post the viral challenge, the inoculum titre was reduced by 2.25 ± 0.33 and ≥4.36 ± 0.23 log 10 TCID 50 on non-porous and porous surfaces, respectively. The half-life of the virus was shorter (13.86 min) on a HaloFilm-coated surface than what has been reported on copper (46.44 min).
(© 2022 Society for Applied Microbiology.)
Databáze: MEDLINE
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