Association between Abnormal Serum Lipid Levels in Early Pregnancy and Development of Preeclampsia.

Autor:	Ameh EL; Department of Obstetrics and Gynaecology, University of Abuja Teaching Hospital, Abuja, Nigeria., Abdullahi HI; Department of Obstetrics and Gynaecology, University of Abuja Teaching Hospital, Abuja, Nigeria., Offiong RA; Department of Obstetrics and Gynaecology, University of Abuja Teaching Hospital, Abuja, Nigeria., Dalili SM; Department of Chemical Pathology, University of Abuja Teaching Hospital, Abuja, Nigeria., Agida ET; Department of Obstetrics and Gynaecology, University of Abuja Teaching Hospital, Abuja, Nigeria., Isah AY; Department of Obstetrics and Gynaecology, University of Abuja Teaching Hospital, Abuja, Nigeria.
Jazyk:	angličtina
Zdroj:	West African journal of medicine [West Afr J Med] 2022 Jul 31; Vol. 39 (7), pp. 761-768.
Abstrakt:	Background: Accurate early biomarkers of oxidative stress, placenta perfusion and vascular resistance and endothelial platelet interaction for prediction of preeclampsia have not been shown to be beneficial for routine clinical use. The study of association between abnormal lipid levels in early pregnancy and preeclampsia is thus necessary in a bid to reduce the progression and severity of complications of preeclampsia. Objective: To determine the association between abnormal lipid levels in early pregnancy and the development of preeclampsia. Materials and Methods: A prospective longitudinal study involving 184 pregnant women with singleton pregnancy who met the inclusion criteria and recruited from the antenatal clinic at gestational age of < 20weeks. Their fasting blood samples were collected for the measurement serum lipid profile. They were monitored until delivery for the development of preeclampsia. The mean values of serum lipid profile were analyzed for association with pre-eclampsia using the statistical package for social sciences (SPSS) version 21.0 and P value of < 0.05 was considered statistically significant. Results: Out of 184 participants, 3 had spontaneous miscarriage and were excluded while 5 were lost to follow up. This left a total of 176 participants who completed the study, 11 of which developed preeclampsia. There was a statistically significant increase in the levels of total cholesterol (TC) and low-density lipoprotein (LDL) in the preeclamptic group. The mean serum lipid levels were 4.8 mmol/L for total cholesterol, 1.87 mmol/L for total triglycerides, 1.3 mmol/L for high-density lipoprotein and 2.67 mmol/L for low-density lipoprotein. Age and parity also showed a causal association with development of preeclampsia. Conclusion: There was an association between elevated serum total cholesterol and low-density lipoprotein with development of preeclampsia later in pregnancy. Competing Interests: The Authors declare that no competing interest exists. (Copyright © 2022 by West African Journal of Medicine.)
Databáze:	MEDLINE
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