Bimetallic Ruthenium Nitrosyl Complexes with Enhanced Two-Photon Absorption Properties for Nitric Oxide Delivery.

Autor: Juarez-Martinez Y; Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077, Toulouse, France., Labra-Vázquez P; Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077, Toulouse, France.; Facultad de Química, Departamento de Química Orgánica, Universidad Nacional Autónoma de México, 04510, México D.F., México., Enríquez-Cabrera A; Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077, Toulouse, France.; Facultad de Química, Departamento de Química Orgánica, Universidad Nacional Autónoma de México, 04510, México D.F., México., Leon-Rojas AF; Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077, Toulouse, France.; Facultad de Química, Departamento de Química Orgánica, Universidad Nacional Autónoma de México, 04510, México D.F., México., Martínez-Bourget D; Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077, Toulouse, France.; Facultad de Química, Departamento de Química Orgánica, Universidad Nacional Autónoma de México, 04510, México D.F., México., Lacroix PG; Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077, Toulouse, France., Tassé M; Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077, Toulouse, France., Mallet-Ladeira S; Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077, Toulouse, France., Farfán N; Facultad de Química, Departamento de Química Orgánica, Universidad Nacional Autónoma de México, 04510, México D.F., México., Santillan R; Departamento de Química, Centro de Investigación y de Estudios del IPN CINVESTAV, Apdo., Postal 14-740, México, D.F., 07000, México., Ramos-Ortiz G; Centro de Investigaciones en Óptica (CIO), A.P. 1-948, 37000, León, Gto., México., Malval JP; Institut de Science des Matériaux de Mulhouse CNRS-UMR 7361, Université de Haute Alsace, 15 rue Jean Starcky, 68057, Mulhouse, France., Malfant I; Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077, Toulouse, France.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Nov 07; Vol. 28 (62), pp. e202201692. Date of Electronic Publication: 2022 Sep 05.
DOI: 10.1002/chem.202201692
Abstrakt: One monometallic and three bimetallic ruthenium nitrosyl (RuNO) complexes are presented and fully characterized in reference to a parent monometallic complex of formula [FTRu(bpy)(NO)] 3+ , where FT is a fluorenyl-substituted terpyridine ligand, and bpy the 2,2'-bipyridine. These new complexes are built with the new ligands FFT, TFT, TFFT, and TF-CC-TF (where an alkyne C≡C group is inserted between two fluorenes). The crystal structures of the bis-RuNO 2 and bis-RuNO complexes built from the TFT ligand are presented. The evolution of the spectroscopic features (intensities and energies) along the series, at one-photon absorption (OPA) correlates well with the TD-DFT computations. A spectacular effect is observed at two-photon absorption (TPA) with a large enhancement of the molecular cross-section (σ TPA ), in the bimetallic species. In the best case, σ TPA is equal to 1523±98 GM at 700 nm, in the therapeutic window of transparency of biological tissues. All compounds are capable of releasing NO⋅ under irradiation, which leads to promising applications in TPA-based drug delivery.
(© 2022 Wiley-VCH GmbH.)
Databáze: MEDLINE
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