Dynamic Load Model Systems of Tendon Inflammation and Mechanobiology.

Autor:	Benage LG; School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR, United States., Sweeney JD; School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR, United States., Giers MB; School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR, United States., Balasubramanian R; School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR, United States.; School of Mechanical, Industrial and Manufacturing Engineering, Oregon State University, Corvallis, OR, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2022 Jul 15; Vol. 10, pp. 896336. Date of Electronic Publication: 2022 Jul 15 (Print Publication: 2022).
DOI:	10.3389/fbioe.2022.896336
Abstrakt:	Dynamic loading is a shared feature of tendon tissue homeostasis and pathology. Tendon cells have the inherent ability to sense mechanical loads that initiate molecular-level mechanotransduction pathways. While mature tendons require physiological mechanical loading in order to maintain and fine tune their extracellular matrix architecture, pathological loading initiates an inflammatory-mediated tissue repair pathway that may ultimately result in extracellular matrix dysregulation and tendon degeneration. The exact loading and inflammatory mechanisms involved in tendon healing and pathology is unclear although a precise understanding is imperative to improving therapeutic outcomes of tendon pathologies. Thus, various model systems have been designed to help elucidate the underlying mechanisms of tendon mechanobiology via mimicry of the in vivo tendon architecture and biomechanics. Recent development of model systems has focused on identifying mechanoresponses to various mechanical loading platforms. Less effort has been placed on identifying inflammatory pathways involved in tendon pathology etiology, though inflammation has been implicated in the onset of such chronic injuries. The focus of this work is to highlight the latest discoveries in tendon mechanobiology platforms and specifically identify the gaps for future work. An interdisciplinary approach is necessary to reveal the complex molecular interplay that leads to tendon pathologies and will ultimately identify potential regenerative therapeutic targets. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Benage, Sweeney, Giers and Balasubramanian.)
Databáze:	MEDLINE
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