Paternal age impairs in vitro embryo and in vivo fetal development in murine.

Autor: Stábile LA; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, 05508 270, Brazil., Mendes CM; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, 05508 270, Brazil., Goissis MD; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, 05508 270, Brazil., Sousa RGB; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, 05508 270, Brazil., Nichi M; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, 05508 270, Brazil., Visintin JA; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, 05508 270, Brazil., Hamilton TRDS; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, 05508 270, Brazil., Assumpção MEOÁ; Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, 05508 270, Brazil. meoaa@usp.br.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jul 29; Vol. 12 (1), pp. 13031. Date of Electronic Publication: 2022 Jul 29.
DOI: 10.1038/s41598-022-16469-9
Abstrakt: The association between advanced paternal age and impaired reproductive outcomes is still controversial. Several studies relate decrease in semen quality, impaired embryo/fetal development and offspring health to increased paternal age. However, some retrospective studies observed no alterations on both seminal status and reproductive outcomes in older men. Such inconsistency may be due to the influence of intrinsic and external factors, such as genetics, race, diet, social class, lifestyle and obvious ethical issues that may bias the assessment of reproductive status in humans. The use of the murine model enables prospective study and owes the establishment of homogeneous and controlled groups. This study aimed to evaluate the effect of paternal age on in vitro embryo development at 4.5 day post conception and on in vivo fetal development at 16 days of gestation. Murine females (2-4 months of age) were mated with young (4-6 months of age) or senile (18-24 months of age) males. We observed decreased in vitro cleavage, blastocyst, and embryo development rates; lighter and shorter fetuses in the senile compared to the young group. This study indicated that advanced paternal age negatively impacts subsequent embryo and fetal development.
(© 2022. The Author(s).)
Databáze: MEDLINE
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