Antioxidant Activity of New Sulphur- and Selenium-Containing Analogues of Potassium Phenosan against H 2 O 2 -Induced Cytotoxicity in Tumour Cells.

Autor: Klyushova LS; Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, 2/12 Timakova Str., 630060 Novosibirsk, Russia., Kandalintseva NV; Department of Chemistry, Novosibirsk State Pedagogical University, 28 Vilyuyskaya Str., 630126 Novosibirsk, Russia., Grishanova AY; Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, 2/12 Timakova Str., 630060 Novosibirsk, Russia.
Jazyk: angličtina
Zdroj: Current issues in molecular biology [Curr Issues Mol Biol] 2022 Jul 07; Vol. 44 (7), pp. 3131-3145. Date of Electronic Publication: 2022 Jul 07.
DOI: 10.3390/cimb44070216
Abstrakt: Among known phenolic antioxidants, the overwhelming majority of compounds have lipophilic properties and the number of known water-soluble compounds is very small. The list of hydrophilic phenolic antioxidants can be expanded via the synthesis of a structurally related series of polyfunctional compounds for further research on their biological activity in vitro. New sulphur- and selenium-containing analogues of antioxidant potassium phenosan were synthesised. In vitro cytotoxicity and cytostaticity as well as antioxidant activity against H 2 O 2 -induced cytotoxicity to human cell lines (HepG2, Hep-2 and MCF-7) were investigated by high-content analysis. A selenium-containing analogue showed higher biological activity than did a sulphur-containing one. As compared to the activity of potassium phenosan, the selenium-containing analogue had a cell line-dependent antioxidant effect against H 2 O 2 -induced cytotoxicity: comparable in HepG2 cells and greater in Hep-2 cells. The selenium-containing analogue significantly increased the death of MCF-7 cells at concentrations above 50 µM. The sulphur-containing analogue has lower biological activity as compared to potassium phenosan and the selenium-containing analogue.
Databáze: MEDLINE
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