Perceived stress associations with hippocampal-dependent behavior and hippocampal subfield volume.

Autor:	Grupe DW; University of Wisconsin-Madison Center for Healthy Minds, 625 W Washington Ave, Madison, WI, 53703, USA.; University of Wisconsin-Madison Waisman Laboratory for Brain Imaging and Behavior, 1500 Highland Ave, Madison, WI, 53705, USA., Barnes AL; University of Wisconsin-Madison Center for Healthy Minds, 625 W Washington Ave, Madison, WI, 53703, USA., Gresham L; University of Wisconsin-Madison Center for Healthy Minds, 625 W Washington Ave, Madison, WI, 53703, USA., Kirvin-Quamme A; University of Wisconsin-Madison Center for Healthy Minds, 625 W Washington Ave, Madison, WI, 53703, USA., Nord E; University of Wisconsin-Madison Center for Healthy Minds, 625 W Washington Ave, Madison, WI, 53703, USA., Alexander AL; University of Wisconsin-Madison Waisman Laboratory for Brain Imaging and Behavior, 1500 Highland Ave, Madison, WI, 53705, USA.; University of Wisconsin-Madison Department of Medical Physics, 1111 Highland Ave, Madison, WI, 53705, USA.; University of Wisconsin-Madison Department of Psychiatry, 6001 Research Park Blvd, Madison, WI, 53719, USA., Abercrombie HC; University of Wisconsin-Madison Center for Healthy Minds, 625 W Washington Ave, Madison, WI, 53703, USA.; University of Wisconsin-Madison Waisman Laboratory for Brain Imaging and Behavior, 1500 Highland Ave, Madison, WI, 53705, USA., Schaefer SM; University of Wisconsin-Madison Center for Healthy Minds, 625 W Washington Ave, Madison, WI, 53703, USA.; University of Wisconsin-Madison Waisman Laboratory for Brain Imaging and Behavior, 1500 Highland Ave, Madison, WI, 53705, USA., Davidson RJ; University of Wisconsin-Madison Center for Healthy Minds, 625 W Washington Ave, Madison, WI, 53703, USA.; University of Wisconsin-Madison Waisman Laboratory for Brain Imaging and Behavior, 1500 Highland Ave, Madison, WI, 53705, USA.; University of Wisconsin-Madison Department of Psychiatry, 6001 Research Park Blvd, Madison, WI, 53719, USA.; University of Wisconsin-Madison Department of Psychology, 1202 W Johnson St, Madison, WI, 53706, USA.
Jazyk:	angličtina
Zdroj:	Neurobiology of stress [Neurobiol Stress] 2022 Jul 08; Vol. 19, pp. 100469. Date of Electronic Publication: 2022 Jul 08 (Print Publication: 2022).
DOI:	10.1016/j.ynstr.2022.100469
Abstrakt:	Background: Individual differences in stress appraisals influence trajectories of risk and resilience following exposure to chronic and acute stressors. Smaller hippocampal volume may contribute to elevated stress appraisals via deficient pattern separation, a process depending on dentate gyrus (DG)/CA3 hippocampal subfields. Here, we investigated links between perceived stress, DG/CA3 volume, and behavioral pattern separation to test hypothesized mechanisms underlying stress-related psychopathology. Methods: We collected the Perceived Stress Scale (PSS) and ratings of subjective stress reactivity during the Trier Social Stress Test (TSST) from 71 adult community participants. We obtained high-resolution T2 MRI scans and used Automatic Segmentation of Hippocampal Subfields to estimate DG/CA3 volume in 56 of these participants. Participants completed the mnemonic similarity task, which provides a behavioral index of pattern separation. Analyses investigated associations between perceived stress, DG/CA3 volume, and behavioral pattern separation, controlling for age, gender, hemisphere, and intracranial volume. Results: Greater PSS scores and TSST subjective stress reactivity were each independently related to poorer behavioral pattern separation, together accounting for 15% of variance in behavioral performance in a simultaneous regression. Contrary to hypotheses, DG/CA3 volume was not associated with either stress measure, although exploratory analyses suggested a link between hippocampal volume asymmetry and PSS scores. Conclusions: We observed novel associations between laboratory and questionnaire measures of perceived stress and a behavioral assay of pattern separation. Additional work is needed to clarify the involvement of the hippocampus in this stress-behavior relationship and determine the relevance of behavioral pattern separation for stress-related disorders. Competing Interests: Dr. Richard Davidson is the founder and president, and sits on the board of, the non-profit organization Healthy Minds Innovations, Inc. The other authors have no disclosures to report. (© 2022 The Authors.)
Databáze:	MEDLINE
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