Increased maternofoetal transfer of antibodies in a murine model of systemic lupus erythematosus, but no immune activation and neuroimmune sequelae in offspring.

Autor: Fonager SV; Department of Biomedicine, Aarhus University, Denmark; Department of Molecular Biology and Genetics, Aarhus University, Denmark., Winther G; Department of Biomedicine, Aarhus University, Denmark., Wittenborn TR; Department of Biomedicine, Aarhus University, Denmark., Jensen L; Department of Biomedicine, Aarhus University, Denmark., Fahlquist-Hagert C; Department of Biomedicine, Aarhus University, Denmark., Hansen LA; Department of Biomedicine, Aarhus University, Denmark., Füchtbauer EM; Department of Molecular Biology and Genetics, Aarhus University, Denmark., Romero-Ramos M; Department of Biomedicine, Aarhus University, Denmark; DANDRITE, Danish Research Institute of Translational Neuroscience, Aarhus University, 8000, Aarhus C, Denmark., Degn SE; Department of Biomedicine, Aarhus University, Denmark. Electronic address: sdegn@biomed.au.dk.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2022 Sep 15; Vol. 370, pp. 577927. Date of Electronic Publication: 2022 Jul 14.
DOI: 10.1016/j.jneuroim.2022.577927
Abstrakt: Maternally transferred autoantibodies can negatively impact the development and health of offspring, increasing the risk of neurodevelopmental disorders. We used embryo transfers to examine maternofoetal immune imprinting in the autoimmune BXSB/MpJ mouse model. Anti-double-stranded DNA antibodies and total immunoglobulins were measured, using allotypes of the IgG subclass to distinguish maternally transferred antibodies from those produced endogenously. Frequencies of germinal center and plasma cells were analysed by flow cytometry. Microglial morphology in offspring CNS was assessed using immunohistochemistry. In contrast to prior findings, our results indicate that BXSB/MpJ mothers display a mild autoimmune phenotype, which does not significantly impact the offspring.
(Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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