Serum uric acid and the risk of ventricular arrhythmias: a systematic review.

Autor:	Dewi IP; Airlangga University, Faculty of Medicine; Duta Wacana Christian University, Faculty of Medicine; Dr. Soetomo General Hospital, Department of Cardiology and Vascular Medicine Surabaya., Putra KNS; Airlangga University, Faculty of Medicine; Dr. Soetomo General Hospital, Department of Cardiology and Vascular Medicine Surabaya., Dewi KP; Airlangga University, Faculty of Medicine; Dr. Soetomo General Hospital, Department of Pulmonology and Respiratory Medicine., Wardhani LFK; Airlangga University, Faculty of Medicine; Dr. Soetomo General Hospital, Department of Cardiology and Vascular Medicine., Julario R; Airlangga University, Faculty of Medicine; Dr. Soetomo General Hospital, Department of Cardiology and Vascular Medicine., Dharmadjati BB; Airlangga University, Faculty of Medicine; Dr. Soetomo General Hospital, Department of Cardiology and Vascular Medicine.
Jazyk:	angličtina
Zdroj:	Kardiologiia [Kardiologiia] 2022 Jun 30; Vol. 62 (6), pp. 70-73. Date of Electronic Publication: 2022 Jun 30.
DOI:	10.18087/cardio.2022.6.n1652
Abstrakt:	Uric acid (UA) is the end product of purine degradation in humans. It promotes inflammation via activation of pro-inflammatory cytokines and increases oxidative stress. The serum uric acid level has emerged as an independent risk factor of cardiovascular disease such as ventricular arrhythmias (VA). Here we had done a systematic review to assess the association between serum UA levels and the occurrence of VA. This systematic review included a total of four clinical studies with 99.383 patients for analysis. The scientific quality of all four studies was good. Three studies showed that serum uric acid levels were associated with VA in many populations. In contrast, one study with a large sample size evaluated that serum uric acid increases premature ventricle contraction prevalence. A significant association between serum uric acid level and VA was found in four studies (p<0.01; p<0.101; p=0.002; p=0.008). In conclusion, this systematic review shows an association between serum UA levels and VA.
Databáze:	MEDLINE
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