Investigation on the elemental profiles of lip cosmetic products: Concentrations, distribution and assessment of potential carcinogenic and non-carcinogenic human health risk for consumer safety.

Autor: Shaaban H; Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, King Faisal Road, P.O. Box 1982, Dammam 31441, Saudi Arabia., Issa SY; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Ahmad R; Department of Natural Products and Alternative Medicine, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O Box # 1982, Dammam 31441, Saudi Arabia., Mostafa A; Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, King Faisal Road, P.O. Box 1982, Dammam 31441, Saudi Arabia., Refai S; College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia., Alkharraa N; College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia., Albaqshi BT; College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia., Hussien D; Department of Pharmacology and Toxicology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, King Faisal Road, P.O. Box 1982, Dammam 31441, Saudi Arabia., Alqarni AM; Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, King Faisal Road, P.O. Box 1982, Dammam 31441, Saudi Arabia.
Jazyk: angličtina
Zdroj: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2022 Jun; Vol. 30 (6), pp. 779-792. Date of Electronic Publication: 2022 Mar 30.
DOI: 10.1016/j.jsps.2022.03.014
Abstrakt: Metal contamination of lip care products can cause potential adverse effects for consumers, hence assessment of human health risks associated with the consumption of these products is inevitable to ensure the consumers' safety. In the presented study, the profiles of 18 elements in 37 of the most popular lip cosmetic products, of various types and brands, sold in the Saudi Arabian markets, were investigated and their associated potential carcinogenic and non-carcinogenic human health risks were assessed. The metal concentrations were determined using inductively coupled plasma mass spectrometry preceded by microwave digestion for sample preparation. In general, the concentrations of the investigated metals were lower than the safe permissible limits with the exception of Cd, Pb and Hg. The results found that Cd was regarded as the primary metal contaminant present in the analyzed lip products contributing to 66.3% of the total determined carcinogenic health risk. Overall, however it was observed that there was no significant non-carcinogenic (hazard index < 1) or carcinogenic (Risk T  < 10 -4 ) health risks associated with the use of the investigated lip products. Although all the calculated values in this study were within the acceptable limits, special attention should be taken in order to prioritize minimizing the trace metals in lip products, especially for Cd, Pb, Ti and Hg. This study could provide vital data needed to ascertain the degree to which heavy metal exposure through cosmetics is prevalent.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2022 The Author(s).)
Databáze: MEDLINE
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