Cecal Microbial Hydrogen Cycling Potential Is Linked to Feed Efficiency Phenotypes in Chickens.

Autor:	Ramírez GA; College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, United States.; Leon H. Charney School of Marine Sciences, Haifa University, Haifa, Israel., Keshri J; College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, United States., Vahrson I; College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, United States., Garber AI; School of Life Sciences, Arizona State University, Tempe, AZ, United States., Berrang ME; Poultry Microbiological Safety and Processing Research Unit, USDA Agricultural Research Service, Athens, GA, United States., Cox NA; Poultry Microbiological Safety and Processing Research Unit, USDA Agricultural Research Service, Athens, GA, United States., González-Cerón F; Departamento de Zootecnia, Chapingo Autonomous University, Estado de Mexico, Mexico.; NutriGenomics Laboratory, Department of Poultry Science, University of Georgia, Athens, GA, United States., Aggrey SE; NutriGenomics Laboratory, Department of Poultry Science, University of Georgia, Athens, GA, United States., Oakley BB; College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in veterinary science [Front Vet Sci] 2022 Jun 21; Vol. 9, pp. 904698. Date of Electronic Publication: 2022 Jun 21 (Print Publication: 2022).
DOI:	10.3389/fvets.2022.904698
Abstrakt:	In chickens, early life exposure to environmental microbes has long-lasting impacts on gastrointestinal (GI) microbiome development and host health and growth, via mechanisms that remain uncharacterized. In this study, we demonstrated that administrating a fecal microbiome transplant (FMT) from adults to day-of-hatch chicks results in significantly higher body mass of birds and decreased residual feed intake (RFI), implying enhanced feed efficiency, at 6 weeks of age. To assess the potential mechanisms through which FMT affects adult bird phenotype, we combined 16 S rRNA gene amplification, metagenomic, and comparative genomic approaches to survey the composition and predicted activities of the resident microbiome of various GI tract segments. Early life FMT exposure had a long-lasting significant effect on the microbial community composition and function of the ceca but not on other GI segments. Within the ceca of 6-week-old FMT birds, hydrogenotrophic microbial lineages and genes were most differentially enriched. The results suggest that thermodynamic regulation in the cecum, in this case via hydrogenotrophic methanogenic and sulfur-cycling lineages, potentially serving as hydrogen sinks, may enhance fermentative efficiency and dietary energy harvest capacity. Our study provides a specific mechanism of action through which early-life microbiome transplants modulate market-relevant phenotypes in poultry and, thereby, may represent a significant advance toward microbiome-focused sustainable agriculture. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Ramírez, Keshri, Vahrson, Garber, Berrang, Cox, González-Cerón, Aggrey and Oakley.)
Databáze:	MEDLINE
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