Higher IL-6 and IL-4 plasma levels in depressed elderly women are influenced by diabetes mellitus.

Autor:	Dias NS; Programa de Pós-Graduação em Neurociências, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., Teixeira AL; Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA. Instituto de Ensino e Pesquisa, Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, MG, Brazil., Diniz BS; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Geriatric Psychiatry Division, Center for Addiction and Mental Health, Toronto, ON Canada., Vieira EL; Laboratório Interdisciplinar de Investigação Médica, UFMG, Belo Horizonte, MG, Brazil., Viana BM; Departamento de Saúde Mental, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil., Barbosa IG; Departamento de Saúde Mental, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil.
Jazyk:	angličtina
Zdroj:	Trends in psychiatry and psychotherapy [Trends Psychiatry Psychother] 2024; Vol. 46, pp. e20220466. Date of Electronic Publication: 2022 Jul 07.
DOI:	10.47626/2237-6089-2022-0466
Abstrakt:	Objective: This study aimed at investigating a set of peripheral cytokines in elderly female patients with MDD, comparing them to controls, and assessing the potential influence of clinical comorbidities on inflammatory markers. Methods: Twenty-five elderly female patients diagnosed with MDD and 19 age-matched female controls were enrolled on this study. Plasma levels of interleukin (IL)-4, IL-6, IL-10, interferon (IFN)-γ and tumor necrosis factor (TNF)-α were evaluated with commercially-available assays. Results: Elderly female patients with MDD exhibited higher plasma IL-6 and IL-4 levels when compared to controls. In a logistic regression model taking cytokine levels, comorbidities, and age into account, only type 2 diabetes mellitus (DM2) remained associated with MDD. Conclusion: Diabetes influences the association between MDD and higher levels of cytokines in elderly female patients. Future studies should take this evidence into account in order to mitigate confounding factors. Competing Interests: No conflicts of interest declared concerning the publication of this article.
Databáze:	MEDLINE
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